197332 | Bcl-2 Inhibitor III, EM20-25 - CAS 141266-44-6 - Calbiochem

197332
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₉ClN₄O₆ 141266-44-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      197332-10MG
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          Plastic ampoule 10 mg
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          Description
          Overview

          This product has been discontinued.



          A cell-permeable pyrimidine-trione compound that sensitizes apoptosis-resistant, Bcl-2-overexpressing leukemic cells to cytotoxic drugs. Shown to bind to Bcl-2, disrupt its interaction with Bax, and activate caspase-9. Also induces PTP (permeability transition pore) opening in both isolated mitochondria and intact cells, without any effect on respiration.

          Catalogue Number197332
          Brand Family Calbiochem®
          Synonyms5-(6-Chloro-2,4-dioxo-1,3,4,10-tetrahydro-2H-9-oxa-1,3-diaza-anthracen-10-yl)-pyrimidine-2,4,6-trione
          References
          ReferencesMilanesi, E., et al. 2006. J. Biol. Chem. 281, 10066.
          Product Information
          CAS number141266-44-6
          ATP CompetitiveN
          FormPale yellow solid
          Hill FormulaC₁₅H₉ClN₄O₆
          Chemical formulaC₁₅H₉ClN₄O₆
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetBcl-2
          Purity≥95% by elemental analysis
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          197332

          References

          Reference overview
          Milanesi, E., et al. 2006. J. Biol. Chem. 281, 10066.

          Brochure

          Title
          Biologics 32.4 ( 1.19 MB )
          Biologics 33.1 ( 1.37 MB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-April-2011 RFH
          Synonyms5-(6-Chloro-2,4-dioxo-1,3,4,10-tetrahydro-2H-9-oxa-1,3-diaza-anthracen-10-yl)-pyrimidine-2,4,6-trione
          DescriptionA cell-permeable pyrimidine-trione compound that sensitizes apoptosis-resistant, Bcl-2-overexpressing leukemic cells to cytotoxic drugs. Shown to bind to Bcl-2, disrupt its interaction with Bax, and activate caspase-9. Also induces PTP (permeability transition pore) opening in both isolated mitochondria and intact cells, without any effect on respiration.
          FormPale yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number141266-44-6
          Chemical formulaC₁₅H₉ClN₄O₆
          Structure formulaStructure formula
          Purity≥95% by elemental analysis
          SolubilityDMSO (2 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Harmful
          ReferencesMilanesi, E., et al. 2006. J. Biol. Chem. 281, 10066.