197330 | Bcl-2 Inhibitor - CAS 383860-03-5 - Calbiochem

197330
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₆N₂O₄ 383860-03-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      197330-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewContains mixture of two tautomers (A and B). A potent, cell-permeable, Bcl-2 inhibitor that competes with Bak BH3 peptide for binding to Bcl-2 and Bcl-xL in vitro (IC50 = 10 µM and 7 µM, respectively). Reduces cell viability and growth in the HL-60 cell line with high Bcl-2 expression (IC50 = 4 µM). Also induces apoptosis in a dose-dependent manner in cancer cells exhibiting high Bcl-2 expression with little effect on cancer cells with low Bcl-2 expression.
          Catalogue Number197330
          Brand Family Calbiochem®
          Synonyms2,9-Dimethoxy-11,12-dihydrodibenzo[c,g][1,2]-diazocine 5,6-dioxide (A) and 5,5ʹ-Dimethoxy-2,2ʹ-dinitrosobenzyl (B)
          References
          ReferencesEnyedy, I.J., et al. 2001. J. Med. Chem. 44, 4313.
          Product Information
          CAS number383860-03-5
          FormGreen solid
          Hill FormulaC₁₆H₁₆N₂O₄
          Chemical formulaC₁₆H₁₆N₂O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetBcl-2
          Primary Target IC<sub>50</sub>10 µM and 7 µM for competing with Bak BH3 peptide for binding to Bcl-2 and Bcl-xL in vitro, respectively; 4 µM for reducing cell viability and growth in the HL-60 cell line with high Bcl-2 expression
          Purity≥97% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze under inert gas (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          197330

          References

          Reference overview
          Enyedy, I.J., et al. 2001. J. Med. Chem. 44, 4313.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-April-2011 RFH
          Synonyms2,9-Dimethoxy-11,12-dihydrodibenzo[c,g][1,2]-diazocine 5,6-dioxide (A) and 5,5ʹ-Dimethoxy-2,2ʹ-dinitrosobenzyl (B)
          DescriptionContains a mixture of two tautomers (A and B). Potent, cell-permeable Bcl-2 inhibitor that competes with Bak BH3 peptide for binding to Bcl-2 and Bcl-XL in vitro (IC50 = 10 µM and 7 µM, respectively). Shown to reduce cell viability (IC50 = 10 µM) and growth in HL60 cells with high levels of Bcl-2 expression (IC50 = 4 µM). Induces apoptosis in a dose-dependent manner in cancer cells expressing high levels of Bcl-2, but has little or no effect on cells that express low levels of Bcl-2.
          FormGreen solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number383860-03-5
          Chemical formulaC₁₆H₁₆N₂O₄
          Structure formulaStructure formula
          Purity≥97% by TLC
          SolubilityDMSO (2.5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze under inert gas (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesEnyedy, I.J., et al. 2001. J. Med. Chem. 44, 4313.