PF126 Bcl-2, C-Terminal Truncated, His•Tag®, Human, Recombinant, E. coli

PF126
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      PF126-50UG
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          Glass bottle 50 μg
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          Description
          OverviewRecombinant, human Bcl-2 without the 17 amino acid mitochondrial targeting sequence at the C-terminus, fused to a His•Tag® sequence, and expressed in E. coli. The truncated protein retains the ability to neutralize pro-apoptotic Bcl-2 family members.
          Catalogue NumberPF126
          Brand Family Calbiochem®
          References
          Product Information
          FormLiquid
          FormulationIn 100 mM KCl, 10 mM HEPES, 20% glycerol, pH 8.0.
          Applications
          Key Applications
          Application NotesNeutralization (see biological activity)
          Biological Information
          Biological activityEC₅₀ = 100-300 nM based on its ability to inhibit 54 nM caspase-8-cleaved human Bid-mediated release of cytochrome c from isolated mouse liver mitochondria
          Purity≥95% by SDS-PAGE
          Species Reactivity
          • Human
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Bcl-2, C-Terminal Truncated, His•Tag®, Human, Recombinant, E. coli SDS

          Title

          Safety Data Sheet (SDS) 

          Bcl-2, C-Terminal Truncated, His•Tag®, Human, Recombinant, E. coli Certificates of Analysis

          TitleLot Number
          PF126
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision18-September-2008 RFH
          ApplicationNeutralization (see biological activity)
          DescriptionRecombinant, human Bcl-2 without the 17 amino acid mitochondrial targeting sequence at the C-terminus, fused to a His-Tag® sequence and expressed in E. coli. The truncated protein retains the ability to neutralize pro-apoptotic Bcl-2 family members.
          BackgroundHuman recombinant protein Bcl-2, minus the 17 amino acid mitochondrial targeting sequence at the C-terminus, was fused to a His-Tag® and expressed in E. coli. The truncated protein retains the ability to neutralize pro-apoptotic Bcl-2 family members.
          Specieshuman
          FormLiquid
          FormulationIn 100 mM KCl, 10 mM HEPES, 20% glycerol, pH 8.0.
          Concentration Label Please refer to vial label for lot-specific concentration
          Purity≥95% by SDS-PAGE
          Biological activityEC₅₀ = 100-300 nM based on its ability to inhibit 54 nM caspase-8-cleaved human Bid-mediated release of cytochrome c from isolated mouse liver mitochondria
          Storage -20°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Standard Handling