196810 | Bax-Inhibiting Peptide, V5 - Calbiochem

196810
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₇H₅₀N₆O₆S

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      196810-5MG
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      Stocked 
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable pentapeptide based on the Ku70-Bax inhibiting domain that offers cytoprotection. Functions as effectively as the Caspase Inhibitor VI (Z-VAD-FMK; Cat. No. 219007) for Bax-mediated apoptosis (~50-200 µM). Also effectively blocks caspase-independent necrotic cell death. Shown to be Ku70 competitive, interact with Bax, prevent its conformational change and mitochondrial translocation. Displays extended stability in culture medium (~3 days). Negative control peptide is also available (Cat. No. 196811).
          Catalogue Number196810
          Brand Family Calbiochem®
          SynonymsBIP-V5, H-VPMLK-OH
          References
          ReferencesYoshida, T., et al. 2004. Biochem. Biophys. Res. Commun. 321, 961.
          Sawada, M., et al. 2003. Nature Cell Biol. 5, 352.
          Product Information
          ATP CompetitiveN
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₂₇H₅₀N₆O₆S
          Chemical formulaC₂₇H₅₀N₆O₆S
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          ApplicationBax-Inhibiting Peptide, V5, CAS 579492-81-2, is a cell-permeable pentapeptide based on the Ku70-Bax inhibiting domain. Acts as an effective Inhibitor for Bax-mediated apoptosis (~50-200 µM).
          Biological Information
          Primary TargetBax mediated apoptosis
          Primary Target IC<sub>50</sub>50-200 µM against Bax mediated apoptosis
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceH-Val-Pro-Met-Leu-Lys-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Storage in glass vials is not recommended as loss of activity may occur.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          196810

          References

          Reference overview
          Yoshida, T., et al. 2004. Biochem. Biophys. Res. Commun. 321, 961.
          Sawada, M., et al. 2003. Nature Cell Biol. 5, 352.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-April-2008 RFH
          SynonymsBIP-V5, H-VPMLK-OH
          DescriptionA cell-permeable pentapeptide derived from the Ku70-Bax inhibiting domain that has been shown to offer protection against apoptosis in cells of human, mouse, rant, and porcine origin. Reported to function as effectively as the caspase inhibitor, Z-VAD-FMK (Caspase Inhibitor VI, Cat. No. 219007) for Bax-mediated apoptosis (~50-200 µM). Also reported to effectively block caspase-independent necrotic cell death. Shown to interact with Bax in a Ku70-competitive manner and prevent its conformational change and mitochondrial translocation. Displays extended stability in culture medium (~3 days).
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₇H₅₀N₆O₆S
          Peptide SequenceH-Val-Pro-Met-Leu-Lys-OH
          Purity≥95% by HPLC
          SolubilityH₂O (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Storage in glass vials is not recommended as loss of activity may occur.
          Toxicity Standard Handling
          ReferencesYoshida, T., et al. 2004. Biochem. Biophys. Res. Commun. 321, 961.
          Sawada, M., et al. 2003. Nature Cell Biol. 5, 352.