203715 | BQ-610 - Calbiochem

203715
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₃₆H₄₇N₇O₆

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      203715-500UG
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      Stocked 
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      Available
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          Plastic ampoule 500 μg
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          Description
          OverviewA highly selective ETA receptor antagonist (IC50 = 20 nM) that attenuates ET-induced reduction in cardiac output. Also inhibits ET-1- and ET-3-induced activation of adenylate cyclase (IC50 = 28.2 nM). BQ-610 is 30-fold more potent than BQ-123 (Cat. No. 05-23-3831) in porcine aortic smooth muscle membrane assay.
          Catalogue Number203715
          Brand Family Calbiochem®
          References
          ReferencesBeyer, M.E., et al. 1999. Hypertension 33, 145.
          Carratu, P., et al. 1997. Am. J. Physiol. 272, L1021.
          Illing, B., et al. 1996. J. Cardiovasc. Pharmacol. 27, 487.
          Han, H., et al. 1995. J. Mol. Cell. Cardiol. 27, 761.
          Ishikawa, K., et al. 1992. in Peptides, Schneider and Eberle, eds. (ESCOM), p. 685.
          Product Information
          ATP CompetitiveN
          FormWhite lyophilized powder
          FormulationSupplied as an ammonium salt.
          Hill FormulaC₃₆H₄₇N₇O₆
          Chemical formulaC₃₆H₄₇N₇O₆
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary TargetETA receptor antagonist
          Primary Target IC<sub>50</sub>20 nM as ETA receptor antagonist that attenuates ET-induced reduction in cardiac output
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceHomopiperidinyl-CO-Leu-D-Trp(CHO)-D-Trp-ONH4
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          203715

          References

          Reference overview
          Beyer, M.E., et al. 1999. Hypertension 33, 145.
          Carratu, P., et al. 1997. Am. J. Physiol. 272, L1021.
          Illing, B., et al. 1996. J. Cardiovasc. Pharmacol. 27, 487.
          Han, H., et al. 1995. J. Mol. Cell. Cardiol. 27, 761.
          Ishikawa, K., et al. 1992. in Peptides, Schneider and Eberle, eds. (ESCOM), p. 685.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-April-2010 JSW
          DescriptionA highly selective endothelin A (ETA) receptor antagonist (IC50 = 20 nM) that attenuates ET-induced reduction in cardiac output. Inhibits ET-1 induced mitogenesis in airway smooth muscle cells in a concentration-dependent manner (IC50 = 20 nM). Also inhibits ET-1 and ET-3 induced activation of adenylate cyclase (IC50 = 28.2 nM). Has been shown to prevent endothelin-induced vasoconstriction. BQ-610 is 30-fold more potent than BQ-123 (Cat. No. 05-23-3831) in a porcine aortic smooth muscle assay.
          FormWhite lyophilized powder
          FormulationSupplied as an ammonium salt.
          Chemical formulaC₃₆H₄₇N₇O₆
          Peptide SequenceHomopiperidinyl-CO-Leu-D-Trp(CHO)-D-Trp-ONH4
          Purity≥90% by HPLC
          SolubilityH₂O (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBeyer, M.E., et al. 1999. Hypertension 33, 145.
          Carratu, P., et al. 1997. Am. J. Physiol. 272, L1021.
          Illing, B., et al. 1996. J. Cardiovasc. Pharmacol. 27, 487.
          Han, H., et al. 1995. J. Mol. Cell. Cardiol. 27, 761.
          Ishikawa, K., et al. 1992. in Peptides, Schneider and Eberle, eds. (ESCOM), p. 685.