197226 | BCRP Inhbitor - Calbiochem

197226
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₂H₁₉N₃O₅

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      197226-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA non-tetrahydroisoquinoline BCRP specific inhibitor based on the anthranilic acid scaffold, that displays an IC50 of 1.39 µM in a Hoechst 33343 assay in stably transfected MDCK BCRP cells, which is ˜50-fold more potent than novobiocin (IC50 = 65 µM), and shows no effect towards other ATP binding cassette (ABC) transporters P-gp and MRP1 at up to a concentration of 10 µM. It is shown to be an allosteric inhibitor in enzyme kinetics assays in the presence of BCRP specific substrates pheophorbide A and imitanib, and does not lead to a decrease in cell viability up to a concentration of 10 µM.
          Catalogue Number197226
          Brand Family Calbiochem®
          SynonymsN-(4-(2-hydroxyethyl)phenyl)-2-(4-nitrobenzamido)benzamide
          References
          ReferencesPick, A. et al. 2010. Chem. Med. Chem. 5, 1498.
          Klinkhammer, W., et al. 2009. Bioorg. Med. Chem. 17, 2524.
          Product Information
          FormOff-white solid
          Hill FormulaC₂₂H₁₉N₃O₅
          Chemical formulaC₂₂H₁₉N₃O₅
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          197226

          References

          Reference overview
          Pick, A. et al. 2010. Chem. Med. Chem. 5, 1498.
          Klinkhammer, W., et al. 2009. Bioorg. Med. Chem. 17, 2524.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision23-February-2011 RFH
          SynonymsN-(4-(2-hydroxyethyl)phenyl)-2-(4-nitrobenzamido)benzamide
          DescriptionA non-tetrahydroisoquinoline BCRP specific inhibitor based on the anthranilic acid scaffold, that displays an IC50 of 1.39 µM in a Hoechst 33343 assay in stably transfected MDCK BCRP cells, which is ˜50-fold more potent than novobiocin (IC50 = 65 µM), and shows no effect towards other ATP binding cassette (ABC) transporters P-gp and MRP1 at up to a concentration of 10 µM. It is shown to be an allosteric inhibitor in enzyme kinetics assays in the presence of BCRP specific substrates pheophorbide A and imitanib, and does not lead to a decrease in cell viability up to a concentration of 10 µM.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₂H₁₉N₃O₅
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesPick, A. et al. 2010. Chem. Med. Chem. 5, 1498.
          Klinkhammer, W., et al. 2009. Bioorg. Med. Chem. 17, 2524.