534360 Autophagy Inhibitor VII - Calbiochem

534360
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₀H₂₆ClN₃

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.34360.0001
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          25 mg
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          Description
          OverviewA cell-permeable tetrahydroacridinamine (THA) derived compound that potently suppresses autophagy (EC = 250 nM) with reduced toxicity (LD50 = 27 µM) in U2OS cells. Shown to induce lysosome deacidification and increase LC3-II protein accumulation. Displays attractive biophysical properties.

          Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
          Catalogue Number534360
          Brand Family Calbiochem®
          Synonyms6-Chloro-N-(1-ethylpiperidin-4-yl)-1,2,3,4-tetrahydroacridin-9-amine, Acridinamine 33, Tetrahydroacridine 33, THA33
          DescriptionAutophagy Inhibitor VII
          References
          ReferencesWang, T., et al. 2015. J. Med. Chem. 58, 3025.
          Product Information
          FormPale yellow solid
          FormulationSupplied as HCl salt.
          Hill FormulaC₂₀H₂₆ClN₃
          Chemical formulaC₂₀H₂₆ClN₃
          Hygroscopic Hygroscopic
          ReversibleY
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Autophagy Inhibitor VII - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Wang, T., et al. 2015. J. Med. Chem. 58, 3025.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-June-2016 JSW
          Synonyms6-Chloro-N-(1-ethylpiperidin-4-yl)-1,2,3,4-tetrahydroacridin-9-amine, Acridinamine 33, Tetrahydroacridine 33, THA33
          DescriptionA cell-permeable tetrahydroacridinamine (THA) derived compound that potently suppresses autophagy (EC = 250 nM) with reduced toxicity (LD50 = 27 µM) in U2OS cells. Shown to induce lysosome deacidification and increase LC3-II protein accumulation. Displays attractive biophysical properties.
          FormPale yellow solid
          FormulationSupplied as HCl salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₀H₂₆ClN₃
          Purity≥98% by HPLC
          SolubilityH₂O (50 mg/ml) or DMSO (1.6 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesWang, T., et al. 2015. J. Med. Chem. 58, 3025.