189484 | Autocamtide-2 Related Inhibitory Peptide II - Calbiochem

189484
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₇₁H₁₂₃N₂₃O₁₉

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      189484-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewAn AIP (Cat. No. 189480) analog, in which Ala3 and Val10 are replaced with Lys and Phe respectively. Acts as a highly specific, potent inhibitor of calmodulin-dependent protein kinase II (CaMKII; IC50 = 4.1 nM). Displays ~10-fold greater potency than AIP. Inhibits PKC at higher concentrations (IC50 = 1 µM) and does not affect the activities of CaMK IV and PKA (IC50 > 100 µM).
          Catalogue Number189484
          Brand Family Calbiochem®
          SynonymsA3K/V10F-AIP, AIP-II, KKKLRRQEAFDAL
          References
          ReferencesIshida, A., et al. 1998. FEBS Lett. 427, 115.
          Product Information
          ATP CompetitiveN
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₇₁H₁₂₃N₂₃O₁₉
          Chemical formulaC₇₁H₁₂₃N₂₃O₁₉
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary TargetCAM Kinase-2
          Primary Target IC<sub>50</sub>4.1 nM
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceH-Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Leu-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          189484

          References

          Reference overview
          Ishida, A., et al. 1998. FEBS Lett. 427, 115.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-April-2008 RFH
          SynonymsA3K/V10F-AIP, AIP-II, KKKLRRQEAFDAL
          DescriptionAn autocamtide-2 related inhibitory peptide (AIP) analog in which Ala3 and Val10 have been replaced with Lys and Phe, respectively. Acts as a highly specific, potent inhibitor of calmodulin-dependent protein kinase II (CaMKII) (IC50 = 4.1 nM). Displays ~10-fold greater potency than AIP (Cat. No. 189480). Inhibits PKC at higher concentrations (IC50 = 1 µM), but does not affect the activities of CaMKIV or PKA (IC50 >100 µM).
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₇₁H₁₂₃N₂₃O₁₉
          Peptide SequenceH-Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Leu-OH
          Purity≥97% by HPLC
          SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesIshida, A., et al. 1998. FEBS Lett. 427, 115.