532605 Aurora A/MYCN Dual Inhibitor, CD532 - Calbiochem

532605
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₆H₂₅F₃N₈O

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.32605.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell permeable diaminopyrimidine derived compound that acts as a highly potent and selective inhibitor of Aurora A (IC50 = 48 nM). Acts by binding to the hinge region via a pyrazole moiety and stabilizes a DFG-in, inactive conformation of Aurora A. Potentiates the loss of the wild-type MYCN protein by disrupting MYCN-Aurora A complex and allowing its ubiquitination and proteasomal degradation in MYCN-amplified SK-N-BE (2) and Kelly neuroblastoma cells (EC50 = 223 and 146.7 nM, respectively). Causes a loss of S-phase entry of cells and allows their accumulation in both G0/G1 and G2 phases. Shown to be effective in vivo with serum t1/2 = 1.5 h in mice.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number532605
          Brand Family Calbiochem®
          SynonymsAurora A Inhibitor, CD532, MYCN Inhibitor, CD532
          References
          ReferencesLee, J.K., et al. 2016. Cancer Cell. 29, In press.
          Gustafson, W. C., et al. 2014. Cancer Cell. 26, 414.
          Product Information
          FormTan solid
          Hill FormulaC₂₆H₂₅F₃N₈O
          Chemical formulaC₂₆H₂₅F₃N₈O
          ReversibleY
          Applications
          Biological Information
          Primary TargetAurora A
          Primary Target IC<sub>50</sub>48 nM
          Secondary targetMYCN
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Aurora A/MYCN Dual Inhibitor, CD532 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Lee, J.K., et al. 2016. Cancer Cell. 29, In press.
          Gustafson, W. C., et al. 2014. Cancer Cell. 26, 414.

          Technical Info

          Title
          Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
          White Paper: Further considerations of antibody validation and usage. (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-March-2015 JSW
          SynonymsAurora A Inhibitor, CD532, MYCN Inhibitor, CD532
          DescriptionA cell permeable diaminopyrimidine derived compound that acts as a highly potent and selective inhibitor of Aurora A (IC50 = 48 nM). Acts by binding to the hinge region via a pyrazole moiety and stabilizes a DFG-in, inactive conformation of Aurora A. Potentiates the loss of the wild-type MYCN protein by disrupting MYCN-Aurora A complex and allowing its ubiquitination and proteasomal degradation in MYCN-amplified SK-N-BE (2) and Kelly neuroblastoma cells (EC50 = 223 and 146.7 nM, respectively). Causes a loss of S-phase entry of cells and allows their accumulation in both G0/G1 and G2 phases. Shown to be effective in vivo with serum t1/2 = 1.5 h in mice.
          FormTan solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₆H₂₅F₃N₈O
          Purity≥97% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLee, J.K., et al. 2016. Cancer Cell. 29, In press.
          Gustafson, W. C., et al. 2014. Cancer Cell. 26, 414.