178273 | Aphidicolin - CAS 38966-21-1 - Calbiochem

178273
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₃₄O₄ 38966-21-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      178273-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable tetracyclic diterpene antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase. Specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses. Potentiates apoptosis induced by arabinosyl nucleosides in leukemia cell lines. Also induces apoptosis in HeLa S3 cells, but inhibits vincristine-induced apoptosis in the p53-negative human prostate cancer cell line PC-3. Also available as a 30 mM solution in DMSO (Cat. No. 504744).
          Catalogue Number178273
          Brand Family Calbiochem®
          References
          ReferencesBorner, M.M., et al. 1995. Cancer Res. 55, 2122.
          Poluha, W., et al. 1995. Oncogene 10, 185.
          Urbani, L., et al. 1995. Exp. Cell Res. 219, 159.
          Schimke, R.T., et al. 1994. Philos. Trans. R. Soc. London. B. Biol. Sci. 345, 311.
          Kuwakado, K., et al. 1993. Biochem. Pharmacol. 46, 1909.
          Hubermann, J.A. 1981. Cell 23, 647.
          Product Information
          CAS number38966-21-1
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₀H₃₄O₄
          Chemical formulaC₂₀H₃₄O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetDNA polymerase α, DNA polymerase δ
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSPB9185000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          178273

          References

          Reference overview
          Borner, M.M., et al. 1995. Cancer Res. 55, 2122.
          Poluha, W., et al. 1995. Oncogene 10, 185.
          Urbani, L., et al. 1995. Exp. Cell Res. 219, 159.
          Schimke, R.T., et al. 1994. Philos. Trans. R. Soc. London. B. Biol. Sci. 345, 311.
          Kuwakado, K., et al. 1993. Biochem. Pharmacol. 46, 1909.
          Hubermann, J.A. 1981. Cell 23, 647.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-April-2008 RFH
          DescriptionA cell-permeable tetracyclic diterpene antibiotic. Cell synchronization agent. Blocks the cell cycle at the early S-phase. Specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses of animal origin. Potentiates apoptosis induced by arabinosyl nucleosides in leukemia cell lines. Also induces apoptosis in HeLaS3 cells, but inhibits vincristine-induced apoptosis in the p53-negative human prostate cancer cell line PC-3.
          FormWhite solid
          CAS number38966-21-1
          RTECSPB9185000
          Chemical formulaC₂₀H₃₄O₄
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityDMSO (50 mg/ml), Ethanol, or Methanol
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Standard Handling
          Merck USA index14, 727
          ReferencesBorner, M.M., et al. 1995. Cancer Res. 55, 2122.
          Poluha, W., et al. 1995. Oncogene 10, 185.
          Urbani, L., et al. 1995. Exp. Cell Res. 219, 159.
          Schimke, R.T., et al. 1994. Philos. Trans. R. Soc. London. B. Biol. Sci. 345, 311.
          Kuwakado, K., et al. 1993. Biochem. Pharmacol. 46, 1909.
          Hubermann, J.A. 1981. Cell 23, 647.