178220 Antipain, Hydrochloride - CAS 37682-72-7 - Calbiochem

178220
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₇H₄₄N₁₀O₆ · HCl 37682-72-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      178220-10MG
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          Plastic ampoule 10 mg
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          178220-5MG
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              Glass bottle 5 mg
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              Description
              OverviewPeptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca2+-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975). Inhibits trypsin-like serine proteases, papain and some cysteine proteases (IC50 = 300 µM).
              Effective concentration: 1-100 µM.
              Catalogue Number178220
              Brand Family Calbiochem®
              References
              ReferencesLyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
              Umezawa, H. 1976. Methods Enzymol. 55, 678.
              Product Information
              CAS number37682-72-7
              ATP CompetitiveN
              FormWhite or slightly yellowish solid
              Hill FormulaC₂₇H₄₄N₁₀O₆ · HCl
              Chemical formulaC₂₇H₄₄N₁₀O₆ · HCl
              Hygroscopic Hygroscopic
              ReversibleN
              Applications
              ApplicationAntipain, Hydrochloride, CAS 37682-72-7, is a peptidyl arginine aldehyde protease inhibitor of trypsin-like serine proteases, papain, and some cysteine proteases (IC50 = 300 µM).
              Biological Information
              Primary TargetTrypsin-like serine proteases
              Primary Target IC<sub>50</sub>300 µM against trypsin-like serine proteases, papain and some cysteine proteases
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSYV9350800
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage +2°C to +8°C
              Hygroscopic Hygroscopic
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              178220

              References

              Reference overview
              Lyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
              Umezawa, H. 1976. Methods Enzymol. 55, 678.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision26-September-2007 RFH
              DescriptionPeptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca2+-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975). Inhibits trypsin-like serine proteases, papain, and some cysteine proteases (IC50 ~500 ng/ml). Effective at concentrations of 1-100 µM.
              FormWhite or slightly yellowish solid
              CAS number37682-72-7
              RTECSYV9350800
              Chemical formulaC₂₇H₄₄N₁₀O₆ · HCl
              SolubilityH₂O (10 mg/ml)
              Storage +2°C to +8°C
              Hygroscopic
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
              Toxicity Standard Handling
              ReferencesLyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
              Umezawa, H. 1976. Methods Enzymol. 55, 678.