MAB354 Anti-Somatostatin Antibody, clone YC7

MAB354
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, Rb IHC R Culture Supernatant Monoclonal Antibody
      Description
      Catalogue NumberMAB354
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Somatostatin Antibody, clone YC7
      Background InformationSomatostatin (also known as growth hormone inhibiting hormone (GHIH) or somatotropin release-inhibiting factor (SRIF) has two active forms, 14 amino acids and 28 amino acids, which are produced by alternate cleavage of the single preproprotein. Somatostatin is expressed widely and acts to inhibit the release of several secondary hormones by binding to high-affinity G-protein coupled somatostatin receptors. Presence of somatostatin has been shown in sympathetic nerves, mucosal cells, myenteric nerves of the gastrointestinal tract, salivary glands and in some parafollicular cells of the thyroid.
      References
      Product Information
      FormatCulture Supernatant
      Control
      • Pancreas, Brain
      PresentationUnPurified tissue culture supernatant containing 0.05% thimerosal.
      Applications
      ApplicationAnti-Somatostatin Antibody, clone YC7 is an antibody against Somatostatin for use in IH.
      Key Applications
      • Immunohistochemistry
      Application NotesImmunohistochemistry at 1:50-1:100 on human brain.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide corresponding to amino acids 1-14 of cyclic somatostatin conjugated to bovine thyroglobulin using carbodiimide.
      CloneYC7
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRat
      SpecificityRecognizes Somatostatin. Shows no cross-reactivity to enkephalins, other endorphins, substance P or CGRP. Partially cross-reacts with somatostatin fragments.
      IsotypeIgG2b
      Species Reactivity
      • Human
      • Rat
      • Rabbit
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells.
      Gene Symbol
      • SST
      • somatostatin
      • somatostatin-28
      • somatostatin-14
      • SMST
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P61278 # Somatostatin inhibits the release of somatotropin.
      SIZE: 116 amino acids; 12736 Da
      SUBCELLULAR LOCATION: Secreted.
      SIMILARITY: SwissProt: P61278 ## Belongs to the somatostatin family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Somatostatin Antibody, clone YC7 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Somatostatin Antibody, clone YC7 Certificates of Analysis

      TitleLot Number
      RAT ANTI-SOMATOSTATIN MONOCLONAL ANTIBODY - 24303702430370
      RAT ANTI-SOMATOSTATIN - 24911142491114
      RAT ANTI-SOMATOSTATIN - 29841472984147
      RAT ANTI-SOMATOSTATIN - 31856053185605
      RAT ANTI-SOMATOSTATIN - 32059213205921
      RAT ANTI-SOMATOSTATIN - 32305193230519
      RAT ANTI-SOMATOSTATIN - 32533103253310
      RAT ANTI-SOMATOSTATIN -25214862521486
      RAT ANTI-SOMATOSTATIN -25499752549975
      RAT ANTI-SOMATOSTATIN -25865242586524

      References

      Reference overviewApplicationSpeciesPub Med ID
      Oxytocin enables maternal behaviour by balancing cortical inhibition.
      Marlin, BJ; Mitre, M; D'amour, JA; Chao, MV; Froemke, RC
      Nature  520  499-504  2015

      Show Abstract
      25874674 25874674
      Control of insulin secretion by cholinergic signaling in the human pancreatic islet.
      Molina, J; Rodriguez-Diaz, R; Fachado, A; Jacques-Silva, MC; Berggren, PO; Caicedo, A
      Diabetes  63  2714-26  2014

      Show Abstract
      24658304 24658304
      Immunofluorescent visualization of mouse interneuron subtypes.
      Molgaard, S; Ulrichsen, M; Boggild, S; Holm, ML; Vaegter, C; Nyengaard, J; Glerup, S
      F1000Research  3  242  2014

      Show Abstract
      ImmunohistochemistryMouse25469233 25469233
      Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission.
      Karayannis, T; Au, E; Patel, JC; Kruglikov, I; Markx, S; Delorme, R; Héron, D; Salomon, D; Glessner, J; Restituito, S; Gordon, A; Rodriguez-Murillo, L; Roy, NC; Gogos, JA; Rudy, B; Rice, ME; Karayiorgou, M; Hakonarson, H; Keren, B; Huguet, G; Bourgeron, T; Hoeffer, C; Tsien, RW; Peles, E; Fishell, G
      Nature  511  236-40  2014

      Show Abstract
      24870235 24870235
      Ldb1 is essential for development of Nkx2.1 lineage derived GABAergic and cholinergic neurons in the telencephalon.
      Zhao, Y; Flandin, P; Vogt, D; Blood, A; Hermesz, E; Westphal, H; Rubenstein, JL
      Developmental biology  385  94-106  2014

      Show Abstract
      24157949 24157949
      Trajectory of the main GABAergic interneuron populations from early development to old age in the rat primary auditory cortex.
      Ouellet, L; de Villers-Sidani, E
      Frontiers in neuroanatomy  8  40  2014

      Show Abstract
      ImmunohistochemistryRat24917792 24917792
      Characterization of excitatory and inhibitory neuron activation in the mouse medial prefrontal cortex following palatable food ingestion and food driven exploratory behavior.
      Gaykema, RP; Nguyen, XM; Boehret, JM; Lambeth, PS; Joy-Gaba, J; Warthen, DM; Scott, MM
      Frontiers in neuroanatomy  8  60  2014

      Show Abstract
      25071465 25071465
      Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.
      Seifi, M; Brown, JF; Mills, J; Bhandari, P; Belelli, D; Lambert, JJ; Rudolph, U; Swinny, JD
      The Journal of neuroscience : the official journal of the Society for Neuroscience  34  10361-78  2014

      Show Abstract
      25080596 25080596
      Prenatal cerebral ischemia triggers dysmaturation of caudate projection neurons.
      McClendon, E; Chen, K; Gong, X; Sharifnia, E; Hagen, M; Cai, V; Shaver, DC; Riddle, A; Dean, JM; Gunn, AJ; Mohr, C; Kaplan, JS; Rossi, DJ; Kroenke, CD; Hohimer, AR; Back, SA
      Annals of neurology  75  508-24  2014

      Show Abstract
      24395459 24395459
      Changes in the cholinergic innervation pattern of porcine ovaries with cysts induced by dexamethasone administration.
      Kozłowska, A; Majewski, M; Jana, B
      Journal of molecular neuroscience : MN  54  10-9  2014

      Show Abstract
      24519145 24519145

      Data Sheet

      Title
      RAT ANTI-SOMATOSTATIN MONOCLONAL ANTIBODY - Data Sheet
      RAT ANTI-SOMATOSTATIN MONOCLONAL ANTIBODY

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies