07-2271 Anti-Serine/threonine-protein kinase 39 Antibody

07-2271
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue Number07-2271
      DescriptionAnti-Serine/threonine-protein kinase 39 Antibody
      Alternate Names
      • serine threonine kinase 39
      • proline-alanine-rich STE20-related kinase
      • Serine/threonine-protein kinase 39
      • serine threonine kinase 39 (STE20/SPS1 homolog, yeast)
      • Ste-20-related kinase
      • Ste20-like protein kinase
      • small intestine SPAK-like kinase
      • STE20/SPS1-related proline-alanine-rich protein kinase
      • STE20/SPS1 homolog
      • Serine/threonine-protein kinase 39
      • serine threonine kinase 39 (STE20/SPS1 homolog, yeast)
      • Ste-20-related kinase
      • Ste20-like protein kinase
      • small intestine SPAK-like kinase
      • STE20/SPS1-related proline-alanine-rich protein kinase
      • STE20/SPS1 homolog
      Background InformationSTE20/SPS-1 related proline alanine-rich kinase (SPAK), or commonly known as Serine/threonine-protein kinase 39, is a member of the SPS1 subfamily of STE20 kinases. Serine/threonine-protein kinase 39 is also very highly conserved between species and has been shown to activate the p38 pathways. Serine/threonine-protein kinase 39 also has a caspase cleavage site and these two functions may mean that Serine/threonine-protein kinase 39 plays a role in stress-activated signaling. Serine/threonine-protein kinase 39 expression is up-regulated by androgens in LNCaP human prostate cancer cells and regulated and phosphorylated by WNK1, which controls the stress signaling pathway. It is activated by WNK4 and then has the ability to stimulate the Na-K-2Cl cotransporter, the inactive version does not posses this ability. Recent research has also made a connection between Serine/threonine-protein kinase 39 and regulation of blood pressure.
      References
      Product Information
      FormatAffinity Purified
      Control
      • HEK293 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationThis Serine/threonine-protein kinase 39 antibody is validated for use in WB for the detection of the Serine/threonine-protein kinase 39 protein.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human Serine/threonine-protein kinase 39.
      HostRabbit
      Species Reactivity
      • Human
      Species Reactivity NoteDemonstrated to react with human.
      Other homologies: Mouse (95% sequence homology). Rat (94% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq].
      Gene Symbol
      • PASK
      • SPAK
      • DCHT
      • SPAK
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: May act as a mediator of stress-activated signals.

      CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

      SUBCELLULAR LOCATION: Cytoplasm Probable. Nucleus Probable. Note: Nucleus when caspase-cleaved Probable.

      TISSUE SPECIFICTY: Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis.

      DOMAIN: PAPA box (proline-alanine repeats) may target the kinase to a specific subcellular location by facilitating interaction with intracellular proteins such as actin or actin-like proteins.

      SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

      Contains 1 protein kinase domain.
      Molecular Weight~60 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HEK293 cell lysate.

      Western Blot Analysis: 1:900 dilution of this antibody detected Serine/threonine-protein kinase 39 on 10 µg of HEK293 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Serine/threonine-protein kinase 39 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Serine/threonine-protein kinase 39 Antibody Certificates of Analysis

      TitleLot Number
      Anti-Serine/threonine-protein - 31914153191415
      Anti-Serine/threonine-protein -26952722695272
      Anti-Serine/threonine-protein kinase 39 - 22984292298429
      Anti-Serine/threonine-protein kinase 39 - 25289932528993
      Anti-Serine/threonine-protein kinase 39 - NRG1845794NRG1845794
      Anti-Serine/threonine-protein kinase 39 Polyclonal Antibody2985075
      Anti-Serine/threonine-protein kinase 39 Polyclonal Antibody2896079
      Anti-Serine/threonine-protein kinase 39 Polyclonal Antibody2887645

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies