MABS178 Anti-STK39 Antibody, clone 5H7.1

MABS178
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R WB, IHC M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABS178
      DescriptionAnti-STK39 Antibody, clone 5H7.1
      Alternate Names
      • STE20/SPS1-related proline-alanine-rich protein kinase
      • Ste-20-related kinase
      • DCHT
      • Serine/threonine-protein kinase 39
      Background InformationSerine/threonine-protein kinase 39 (STK39), also known as STE20/SPS-1 related proline alanine-rich kinase (SPAK), is a member of the SPS1 subfamily of STE20 kinases. STK39 is also very highly conserved between species and has been shown to activate the p38 pathways. STK39 also has a caspase cleavage site and these two functions may mean that STK39 plays a role in stress-activated signaling. STK39 expression is up-regulated by androgens in LNCaP human prostate cancer cells and regulated and phosphorylated by WNK1, which controls the stress signaling pathway. It is activated by WNK4 and then has the ability to stimulate the Na-K-2Cl cotransporter, the inactive version does not possess this ability. Recent research has also made a connection between STK39 and regulation of blood pressure.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-STK39 Antibody, clone 5H7.1 is a highly specific mouse monoclonal antibody, that targets STK39 & has been tested in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern Blotting Analysis: 1.0 µg/mL from a representative lot detected STK39 in 10 µg of mouse and rat brain tissue lysate.
      Immunohistochemistry Analysis: A 1:500-2,000 dilution from a representative lot detected STK39 in human cerebellum sections and rat hindbrain sections tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the C-terminus of human STK39.
      EpitopeC-terminus
      Clone5H7.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody recognizes the C-terminus of STK39.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • STK39
      • SPAK
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~60 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human brain tissue lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected STK39 in 10 µg of human brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Related Products & Applications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies