05-164 Anti-PLCβ-1 Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, H, M, R IP M Purified Monoclonal Antibody
      Catalogue Number05-164
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-PLCβ-1 Antibody
      Product Information
      Presentation100mM Tris-glycine, pH 7.4, 0.15M NaCl with 0.05% sodium azide
      ApplicationDetect PLCβ-1 using this Anti-PLCβ-1 Antibody validated for use in IP.
      Key Applications
      • Immunoprecipitation
      Biological Information
      ImmunogenMixed monoclonal antibodies raised against purified bovine PLCβ-1
      SpecificityPLCβ-1, also recognize the 100kDa and 41kDa fragments of PLCβ-1.1
      Isotypemixed IgGs
      Species Reactivity
      • Bovine
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene.
      Gene Symbol
      • PLCB1
      • PLC-beta-1
      • PLC-154
      • PLC-I
      • KIAA0581
      • FLJ45792
      • 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate
      • PI-PLC
      • inositoltrisphosphohydrolase
      Purification MethodProtein G Chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9NQ66 # The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
      COFACTOR: Calcium.
      SIZE: 1216 amino acids; 138567 Da
      SIMILARITY: SwissProt: Q9NQ66 ## Contains 1 C2 domain. & Contains 1 PI-PLC X-box domain. & Contains 1 PI-PLC Y-box domain.
      MISCELLANEOUS: The receptor-mediated activation of PLC-beta-1 is mediated by two G-protein alpha subunits, alpha-Q and alpha-11.
      Molecular Weight150 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoprecipition of PLCβ-1 from a bovine brain membrane preparation, subsequent immunoblotting performed by the antibody
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information


      Anti-PLCβ-1 Antibody SDS


      Safety Data Sheet (SDS) 

      Anti-PLCβ-1 Antibody Certificates of Analysis

      TitleLot Number
      Anti-PLCb-1 (mixed mouse monoclonal IgGs) - 21069532106953
      Anti-PLCb-1 (mixed mouse monoclonal IgGs) - 21899352189935
      Anti-PLCb-1 (mixed mouse monoclonal IgGs) - JBC1940041JBC1940041
      Anti-PLCb-1 - 22995672299567
      Anti-PLCbeta;-1 - 1249512495
      Anti-PLCbeta;-1 - 1812018120
      Anti-PLCbeta;-1 - 2157821578
      Anti-PLCbeta;-1 - 2599625996
      Anti-PLCβ-1 (mixed mouse monoclonal IgGs) - 23187742318774
      Anti-PLCβ-1 (mixed mouse monoclonal IgGs) - 24333772433377


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      Tomicic, MT; Aasland, D; Naumann, SC; Meise, R; Barckhausen, C; Kaina, B; Christmann, M
      Cancer research  74  5585-96  2014

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      Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage.
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      Nucleic acids research  38  6418-32  2010

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      FASEB J., 23: 957-66 (2009)  2009

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      Cardiovascular research  49  118-26  2001

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      11121803 11121803
      Changes in sarcolemmal PLC isoenzymes in postinfarct congestive heart failure: partial correction by imidapril.
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      The American journal of physiology  277  H40-9  1999

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      P Sánchez-Blázquez, J Garzón
      The Journal of pharmacology and experimental therapeutics  285  820-7  1998

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      Phospholipase C-beta1 is present in the botrysome, an intermediate compartment-like organelle, and Is regulated by visual experience in cat visual cortex
      Kind, P. C., et al
      J Neurosci, 17:1471-80 (1997)  1997

      Immunoprecipitation9006988 9006988
      A new phospholipase C delta 4 is induced at S-phase of the cell cycle and appears in the nucleus
      Liu, N., et al
      J Biol Chem, 271:355-60 (1996)  1996

      Immunoblotting (Western)8550586 8550586
      Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid beta-protein production in human neuronal NT2N cells
      Wolf, B. A., et al
      J Biol Chem, 270:4916-22 (1995)  1995

      Immunoblotting (Western)7876266 7876266
      Monoclonal antibodies to three phospholipase C isozymes from bovine brain.
      Suh, P G, et al.
      J. Biol. Chem., 263: 14497-504 (1988)  1988

      Show Abstract
      2459119 2459119