AB15690 Anti-Orexin A Antibody

AB15690
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R ELISA Ch Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberAB15690
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Orexin A Antibody
      Alternate Names
      • Hypocretin 1
      References
      Product Information
      FormatAffinity Purified
      PresentationLiquid in PBS with 0.02% sodium azide.
      Applications
      ApplicationAnti-Orexin A Antibody detects level of Orexin A & has been published & validated for use in ELISA.
      Key Applications
      • ELISA
      Application NotesELISA: 1:200-1:1,000 when using as the coating antibody and 1:2,000-1:5,000 when using as the detection antibody in a sandwich ELISA.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic peptide from the N-terminus of human Orexin A.
      HostChicken
      SpecificityOrexin A
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a hypothalamic neuropeptide precusor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis.
      Gene Symbol
      • HCRT
      • Hcrt
      • PPOX
      • PPORX
      • Hypocretin
      • OX
      • orexin
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O43612 # Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
      SIZE: 131 amino acids; 13363 Da
      SUBCELLULAR LOCATION: Rough endoplasmic reticulum (By similarity). Cytoplasmic vesicle (By similarity). Cell junction, synapse (By similarity). Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses (By similarity).
      TISSUE SPECIFICITY: Abundantly expressed in subthalamic nucleus but undetectable in other brain regions tested (hypothalamus was not tested) and in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.
      PTM: Specific enzymatic cleavages at paired basic residues yield the different active peptides.
      DISEASE: SwissProt: O43612 # Defects in HCRT are a cause of narcolepsy [MIM:161400]. Narcolepsy is a neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, such as cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is associated with a deficient orexin system. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most narcoleptic patients. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed.
      SIMILARITY: SwissProt: O43612 ## Belongs to the orexin family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Orexin A Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Orexin A Antibody Certificates of Analysis

      TitleLot Number
      CHICKEN ANTI-OREXIN A AFFINITY PURIFIED POLYCLONAL ANTIBODY - 23735212373521
      CHICKEN ANTI-OREXIN A AFFINITY PURIFIED POLYCLONAL ANTIBODY - 24269822426982
      CHICKEN ANTI-OREXIN A -28577332857733
      CHICKEN ANTI-OREXIN A AFFINITY PURIFIED POLYCLONAL ANTIBODY3150449
      CHICKEN ANTI-OREXIN A AFFINITY PURIFIED POLYCLONAL ANTIBODY - 20202982020298
      CHICKEN ANTI-OREXIN A AFFINITY PURIFIED POLYCLONAL ANTIBODY - 22110392211039
      CHICKEN ANTI-OREXIN A AFFINITY PURIFIED POLYCLONAL ANTIBODY - 22763682276368
      CHICKEN ANTI-OREXIN A AFFINITY PURIFIED POLYCLONAL ANTIBODY - 22909792290979

      References

      Reference overviewPub Med ID
      Gene expression and protein distribution of orexins and orexin receptors in rat retina.
      F Liu,G Z Xu,L Wang,S X Jiang,X L Yang,Y M Zhong
      Neuroscience  189  2011

      Show Abstract
      21621592 21621592

      Data Sheet

      Title
      Anti-Orexin A - Data Sheet

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies