07-2264 Anti-OSR1 Antibody

07-2264
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M WB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue Number07-2264
      DescriptionAnti-OSR1 Antibody
      Alternate Names
      • oxidative-stress responsive 1
      • serine/threonine-protein kinase OSR1
      • Oxidative stress-responsive 1 protein
      Background InformationOdd-skipped-related protein 1 (OSR1) is expressed during the beginning stages of embryogenesis in the intermediate mesoderm and in patterns during limb and branchial arch development. It has been shown that OSR1 plays a critical part in creating kidney precursor cells and regulating differentiation into kidney tubular tissue. OSR1 may play a role in limiting endoderm differentiation from mesendoderm. Expression of OSR1 is controlled by Runx2 and Ikzf1 and is key in development of embryonic, heart and urogenital tissue.
      References
      Product Information
      FormatAffinity Purified
      Control
      • HEK293 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationDetect the OSR1 protein using this Anti-OSR1 validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human OSR1.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteDemonstrated to react with human and mouse. Other homologies: Rat (96% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq].
      Gene Symbol
      • OSR1
      • OXSR1
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton.

      CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

      COFACTOR: Magnesium.

      ENZYME REGULATION: By autophosphorylation on threonine.

      SUBUNIT STRUCTURE: Binds to and phosphorylates PAK1. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. Binds to and phosphorylates RELL1, RELL2 AND RELT. UniProtKB Q6P9R2

      TISSUE SPECIFICITY: Ubiquitously expressed in all tissue examined.

      PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.

      SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

      Contains 1 protein kinase domain.

      SEQUENCE CAUTION: The sequence AAP97192.1 differs from that shown. Reason: Erroneous initiation.

      The sequence BAA83053.2 differs from that shown. Reason: Frameshift at position 63.
      Molecular Weight~58 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HEK293 cell lysate.

      Western Blot Analysis: 1:1,000 dilution of this antibody detected OSR1 on 10 µg of HEK293 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications