AB1518 Anti-Neurofibrillary Tangles Antibody

AB1518
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H ELISA, WB, IHC, IH(P) Rb Serum Polyclonal Antibody
      Description
      Catalogue NumberAB1518
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Neurofibrillary Tangles Antibody
      References
      Product Information
      FormatSerum
      PresentationRabbit antisera with 0.01% thimerosal.
      Applications
      ApplicationAnti-Neurofibrillary Tangles Antibody is an antibody against Neurofibrillary Tangles for use in ELISA, WB, IH, IH(P).
      Key Applications
      • ELISA
      • Western Blotting
      • Immunohistochemistry
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry on paraffin, vibratome and frozen sections: >=1:200, >=1:2,000, respectively.

      Western blotting: >=1:500.

      ELISA using immunogen peptide: >=1:4,000.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenNeurofibrillary tangles which were extracted in boiling SDS and purified by sucrose gradient centrifugation.
      HostRabbit
      SpecificitySpecifically stains neurofibrillary tangles and degenerating plaque neurites in cases of Alzheimer's disease, Down's Syndrome and normal aged individuals.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Neurofibrillary Tangles Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Neurofibrillary Tangles Antibody Certificates of Analysis

      TitleLot Number
      Anti-Neurofibrillary Tangles - 20458402045840
      Anti-Neurofibrillary Tangles - 22119002211900
      Anti-Neurofibrillary Tangles - 22936782293678
      Anti-Neurofibrillary Tangles - 28291572829157
      Anti-Neurofibrillary Tangles - 32088183208818
      Anti-Neurofibrillary Tangles - 32602383260238
      Anti-Neurofibrillary Tangles - JC1655613JC1655613
      Anti-Neurofibrillary Tangles - NG1718502NG1718502
      Anti-Neurofibrillary Tangles -25042812504281
      Anti-Neurofibrillary Tangles -26325352632535

      References

      Reference overviewApplicationPub Med ID
      Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A.
      Wang, HY; Bakshi, K; Frankfurt, M; Stucky, A; Goberdhan, M; Shah, SM; Burns, LH
      The Journal of neuroscience : the official journal of the Society for Neuroscience  32  9773-84  2012

      Show Abstract
      22815492 22815492
      Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats.
      Mustroph, ML; King, MA; Klein, RL; Ramirez, JJ
      Behavioural brain research  233  141-8  2012

      Show Abstract
      22561128 22561128
      Focal expression of mutated tau in entorhinal cortex neurons of rats impairs spatial working memory.
      Ramirez, JJ; Poulton, WE; Knelson, E; Barton, C; King, MA; Klein, RL
      Behavioural brain research  216  332-40  2011

      Show Abstract
      20727915 20727915
      GRK5 deficiency leads to early Alzheimer-like pathology and working memory impairment.
      Suo, Z; Cox, AA; Bartelli, N; Rasul, I; Festoff, BW; Premont, RT; Arendash, GW
      Neurobiology of aging  28  1873-88  2007

      Show Abstract
      Immunofluorescence17011668 17011668
      A neurofilament antibody recognizes a subset of pyramidal cells in the human neocortex that are preserved in Alzheimer's disease.
      Radenahmad, N; Neal, JW; Wilcock, G; Pearson, RC
      Neuropathology and applied neurobiology  29  316-20  2003

      Immunohistochemistry12787329 12787329
      Rapid tau aggregation and delayed hippocampal neuronal death induced by persistent thrombin signaling.
      Suo, Z; Wu, M; Citron, BA; Palazzo, RE; Festoff, BW
      The Journal of biological chemistry  278  37681-9  2003

      Show Abstract
      Immunocytochemistry, Immunoblotting (Western)12821672 12821672
      Comparative analysis of an improved thioflavin-s stain, Gallyas silver stain, and immunohistochemistry for neurofibrillary tangle demonstration on the same sections.
      Anyang Sun, Xuan V Nguyen, Guoying Bing
      The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society  50  463-72  2002

      Show Abstract
      11897799 11897799
      Isolation and partial characterization of neurofibrillary tangles and amyloid plaque core in Alzheimer's disease: immunohistological studies.
      Gorevic, P D, et al.
      J. Neuropathol. Exp. Neurol., 45: 647-64 (1986)  1986

      Show Abstract
      3772397 3772397
      Anti-PHF antibodies: an immunohistochemical marker of the lesions of the Alzheimer's disease. Characterization and comparison with Bodian's silver impregnation.
      Persuy, P, et al.
      Virchows Archiv. A, Pathological anatomy and histopathology, 407: 13-23 (1985)  1985

      Show Abstract
      2409667 2409667
      Neurofibrillary tangles of Alzheimer's disease: an immunohistochemical study.
      Brion, J P, et al.
      J. Submicrosc. Cytol., 17: 89-96 (1985)  1985

      Show Abstract
      3973960 3973960

      Data Sheet

      Title
      Anti-Neurofibrillary Tangles - Data Sheet