07-356 Anti-NR3A Antibody

07-356
200 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, Ma, R WB Rb Purified Polyclonal Antibody
      Description
      Catalogue Number07-356
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-NR3A Antibody
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
      Applications
      ApplicationAnti-NR3A Antibody is an antibody against NR3A for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      Immunogenpeptide corresponding to amino acids 1098-1113 (SRKTELEEYQKTNRTC) of rat NR3A
      HostRabbit
      SpecificityNR3A
      IsotypeIgG
      Species Reactivity
      • Human
      • Mammals
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity.
      Gene Symbol
      • GRIN3A
      • KIAA1973
      • Glutamate
      • NMDAR-L
      • NR3A
      • FLJ45414
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q8TCU5 # NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity).
      SIZE: 1115 amino acids; 125595 Da
      SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex with GRIN1, GRIN2A or GRIN2B and PPP2CB. Probably interacts with PPP2CB. No complex with PPP2CB is detected when NMDARs are stimulated by NMDA (By similarity).
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Note=Enriched in post-synaptic plasma membrane and post-synaptic densities. Requires the presence of GRIN1 to be targeted at the plasma membrane (By similarity).DEVELOPMENTAL STAGE: Expressed in fetal brain.
      PTM: N-glycosylated (By similarity).
      SIMILARITY: SwissProt: Q8TCU5 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
      Molecular Weight130kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot in a rat brain microsomal protein preparation
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-NR3A Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-NR3A Antibody Certificates of Analysis

      TitleLot Number
      Anti-NR3A - 2240322403
      Rabbit Anti-NR3A3046665
      Rabbit Anti-NR3A Polyclonal Antibody - 21237112123711
      Rabbit Anti-NR3A Polyclonal Antibody - 24335462433546
      Rabbit Anti-NR3A - 32022503202250
      Rabbit Anti-NR3A - 33131503313150
      Rabbit Anti-NR3A -25140522514052
      Rabbit Anti-NR3A -26200882620088
      Rabbit Anti-NR3A -27684372768437
      Rabbit Anti-NR3A -28347332834733

      References

      Reference overviewApplicationPub Med ID
      The GluN3A subunit exerts a neuroprotective effect in brain ischemia and the hypoxia process.
      Wang, H; Yan, H; Zhang, S; Wei, X; Zheng, J; Li, J
      ASN neuro  5  231-42  2013

      Show Abstract
      23883441 23883441
      Gestational methylazoxymethanol exposure leads to NMDAR dysfunction in hippocampus during early development and lasting deficits in learning.
      Snyder, MA; Adelman, AE; Gao, WJ
      Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology  38  328-40  2013

      Show Abstract
      Western Blotting22968815 22968815
      Genetic deletion of NR3A accelerates glutamatergic synapse maturation.
      Henson, MA; Larsen, RS; Lawson, SN; Pérez-Otaño, I; Nakanishi, N; Lipton, SA; Philpot, BD
      PloS one  7  e42327  2012

      Show Abstract
      Western Blotting22870318 22870318
      N-methyl-D-aspartate receptor subunit NR3a expression and function in principal cells of the collecting duct.
      Sproul, A; Steele, SL; Thai, TL; Yu, S; Klein, JD; Sands, JM; Bell, PD
      American journal of physiology. Renal physiology  301  F44-54  2011

      Show Abstract
      21429969 21429969
      Developmental regulation of the NMDA receptor subunits, NR3A and NR1, in human prefrontal cortex.
      Henson, MA; Roberts, AC; Salimi, K; Vadlamudi, S; Hamer, RM; Gilmore, JH; Jarskog, LF; Philpot, BD
      Cerebral cortex (New York, N.Y. : 1991)  18  2560-73  2008

      Show Abstract
      18296432 18296432
      Region specific regulation of NR1 in rhesus monkeys following chronic antipsychotic drug administration.
      O'Connor JA, Hasenkamp W, Horman BM, Muly EC, Hemby SE.
      Biological psychiatry  60  659-62  2006

      Show Abstract
      16806093 16806093
      NR3 protein expression in trigeminal neurons during postnatal development.
      Kohji Ishihama, Jack E Turman
      Brain research  1095  12-6  2006

      Show Abstract
      16709403 16709403
      Prenatal development of NMDA receptor composition and function in trigeminal neurons.
      Kohji Ishihama, Mikihiko Kogo, Satoshi Wakisaka, Jack E Turman, Kohji Ishihama, Mikihiko Kogo, Satoshi Wakisaka, Jack E Turman
      Archives of histology and cytology  68  321-35  2005

      Show Abstract
      16477151 16477151
      Differential regulation of ionotropic glutamate receptor subunits following cocaine self-administration.
      Hemby, SE; Horman, B; Tang, W
      Brain research  1064  75-82  2005

      Show Abstract
      16277980 16277980
      Amino terminal domain regulation of NMDA receptor function.
      Herin, Greta Ann and Aizenman, Elias
      Eur. J. Pharmacol., 500: 101-11 (2004)  2004

      Show Abstract
      15464024 15464024

      Brochure

      Title
      Pathways and Biomarkers of Glutamatergic Synapse Flyer (EMD)

      Data Sheet

      Title
      Rabbit Anti-NR3A