AB5486 Anti-Macrophage Scavenger Receptor Type 1 Antibody

AB5486
200 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H ELISA, WB, IH(P) Gt Serum Polyclonal Antibody
      Description
      Catalogue NumberAB5486
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Macrophage Scavenger Receptor Type 1 Antibody
      Alternate Names
      • MSR
      Background InformationMacrophage scavenger receptors (MSR) are membrane glycoproteins that mediate the recognition and uptake of a wide variety of negatively charged macromolecules. There are two types of these receptors that differ in the C-terminal region. MSR has a key role in scavenging a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta). While the normal role of MSR is associated with cell adhesion and host defense mechanisms, it also has been implicated in the development of atherosclerosis and Ab deposition in Alzheimer's disease (AD).The observation that the 4 allele of the apolipoprotein E gene is associated with an increased risk for AD has lead to the investigation of lipoprotein metabolism in the brain of AD patients. The type I MSR has been found to be expressed on microglia and Mato cells, but not astrocytes or neurons. In AD brain, MSR type I is strongly expressed by microglia cells that are associated with senile plaques. Because the senile plaques contain AGEs, which are a source of free radicals that could result in oxidative damage to the brain, MSR may have a role in mediating the endocytosis of AGEs.
      References
      Product Information
      FormatSerum
      PresentationGoat serum. Liquid containing 0.01% thimerosal.
      Applications
      ApplicationDetect Macrophage Scavenger Receptor Type 1 using this Anti-Macrophage Scavenger Receptor Type 1 Antibody validated for use in ELISA, WB, IH(P).
      Key Applications
      • ELISA
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry: 1:200 on paraffin embedded, formalin fixed human brain.

      Western blot: 1:2,000

      ELISA against immunogen peptide: 1:97,000

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide that corresponds to amino acids 325-342 of the C-terminus of the human MSR type I.
      HostGoat
      SpecificitySpecific for human macrophage scavenger receptor type I (MSR type I). This antibody immunolabels amyloid plaques in formalin-fixed paraffin sections from Alzheimer's Disease (AD) brain.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
      Gene Symbol
      • MSR1
      • SR-A
      • SCARA1
      • phSR2
      • phSR1
      • CD204
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P21757 # Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL).
      SIZE: 451 amino acids; 49762 Da
      SUBUNIT: Homotrimer.
      SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
      SIMILARITY: SwissProt: P21757 ## Contains 1 collagen-like domain. & Contains 1 SRCR domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Macrophage Scavenger Receptor Type 1 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Macrophage Scavenger Receptor Type 1 Antibody Certificates of Analysis

      TitleLot Number
      GOAT ANTI-MACROPHAGE SCAVENGER RECEPTOR TYPE 1 -27511882751188
      GOAT ANTI-MACROPHAGE SCAVENGER RECEPTOR TYPE 1 POLYCLONAL ANTIBODY3040525
      GOAT ANTI-MACROPHAGE SCAVENGER RECEPTOR TYPE 1 POLYCLONAL ANTIBODY2908054
      GOAT ANTI-MACROPHAGE SCAVENGER RECEPTOR TYPE 1 POLYCLONAL ANTIBODY - 20547832054783
      GOAT ANTI-MACROPHAGE SCAVENGER RECEPTOR TYPE 1 POLYCLONAL ANTIBODY - 22727302272730

      References

      Reference overviewPub Med ID
      Inhibition of antigen trafficking through scavenger receptor A.
      Raycroft, MT; Harvey, BP; Bruck, MJ; Mamula, MJ
      The Journal of biological chemistry  287  5310-6  2012

      Show Abstract
      22215667 22215667
      MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages.
      Mohamed S Arredouani, Aiyappa Palecanda, Henry Koziel, Yuh-Ching Huang, Amy Imrich, Timothy H Sulahian, Yao Yu Ning, Zhiping Yang, Timo Pikkarainen, Marko Sankala, Sara O Vargas, Motohiro Takeya, Karl Tryggvason, Lester Kobzik
      Journal of immunology (Baltimore, Md. : 1950)  175  6058-64  2005

      Show Abstract
      16237101 16237101

      Data Sheet

      Title
      GOAT ANTI-MACROPHAGE SCAVENGER RECEPTOR TYPE 1

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies