PC342 Anti-MMP-2 (Ab-7) Rabbit pAb

PC342
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityHostAntibody Type
      H, M Rb Polyclonal Antibody

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      PC342-100UG
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          Plastic ampoule 100 μg
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          Description
          Overview

          This product has been discontinued.



          Recognizes the ~72 kDa latent form of the MMP-2 protein. Cross-reacts with recombinant MMP-9 at high concentrations but does not cross-react with native MMP-9.

          Catalogue NumberPC342
          Brand Family Calbiochem®
          SynonymsAnti-Matrix Metalloproteinase 2, Anti-Gelatinase A, Anti-72 kDa Gelatinase
          References
          ReferencesNikkari, S.T., et al. 1996. Am. J. Pathol. 149, 1427.
          Soini, Y., et al. 1994. J. Histochem. And Cytochemistry 42, 945.
          Autio-Harmainen, H., et al. 1993. Lab. Invest. 69, 312.
          Cottam, D.W. and Rees, R.C. 1993. Intl J. Oncol. 2, 861.
          Schnaper, H.W., et al. 1993. J. Cell. Physiol. 156, 235.
          Stetler-Stevenson, W.G., et al. 1993. FASEB J. 7, 1434.
          Autio-Harmainen, H., et al. 1992. Lab. Invest. 67, 191.
          Fridman, R., et al. 1992. J. Biol. Chem. 267, 15398.
          Margulies, I.M., et al. 1992. Cancer Epidemiology, Biomarkers and Prevention 1, 467.
          Woessner, J.F. 1991. FASEB J. 5, 2145.
          Liotta, L.A. and Stetler-Stevenson, W.G. 1990. in Seminars in Cancer Biology, ed. M.M. Gottesman. Vol. 1(2), 99.
          Product Information
          FormLiquid
          FormulationIn 1X PBS, 0.2% BSA.
          Positive controlConditioned medium from HT-1080 cells or recombinant MMP-2
          Preservative≤0.1% sodium azide
          Applications
          Key Applications Immunoblotting (Western Blotting)
          Immunoprecipitation
          Not Frozen Sections
          Application NotesFrozen Sections (not recommended
          Immunoblotting (2 µg/ml)
          Immunoprecipitation (1 µg/sample)
          Application CommentsThis antibody will cross-react with recombinant human MMP-9 at high concentrations of protein. No cross-reactivity seen with native MMP-9. Antibody should be titrated for optimal results in individual systems.
          Biological Information
          Immunogenrecombinant, human pro-MMP-2
          ImmunogenHuman
          HostRabbit
          IsotypeIgG
          Species Reactivity
          • Human
          • Mouse
          Antibody TypePolyclonal Antibody
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFor long-term storage, aliquot and freeze (-20°C). Avoid freeze/thaw cycles.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Anti-MMP-2 (Ab-7) Rabbit pAb SDS

          Title

          Safety Data Sheet (SDS) 

          Anti-MMP-2 (Ab-7) Rabbit pAb Certificates of Analysis

          TitleLot Number
          PC342

          References

          Reference overview
          Nikkari, S.T., et al. 1996. Am. J. Pathol. 149, 1427.
          Soini, Y., et al. 1994. J. Histochem. And Cytochemistry 42, 945.
          Autio-Harmainen, H., et al. 1993. Lab. Invest. 69, 312.
          Cottam, D.W. and Rees, R.C. 1993. Intl J. Oncol. 2, 861.
          Schnaper, H.W., et al. 1993. J. Cell. Physiol. 156, 235.
          Stetler-Stevenson, W.G., et al. 1993. FASEB J. 7, 1434.
          Autio-Harmainen, H., et al. 1992. Lab. Invest. 67, 191.
          Fridman, R., et al. 1992. J. Biol. Chem. 267, 15398.
          Margulies, I.M., et al. 1992. Cancer Epidemiology, Biomarkers and Prevention 1, 467.
          Woessner, J.F. 1991. FASEB J. 5, 2145.
          Liotta, L.A. and Stetler-Stevenson, W.G. 1990. in Seminars in Cancer Biology, ed. M.M. Gottesman. Vol. 1(2), 99.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-October-2007 RFH
          SynonymsAnti-Matrix Metalloproteinase 2, Anti-Gelatinase A, Anti-72 kDa Gelatinase
          ApplicationFrozen Sections (not recommended
          Immunoblotting (2 µg/ml)
          Immunoprecipitation (1 µg/sample)
          DescriptionPurified rabbit polyclonal antibody. Recognizes the ~72 kDa latent form of MMP-2.
          BackgroundMatrix metalloproteinases (MMPs) are a family of enzymes that are responsible for the degradation of extracellular matrix components such as collagen, laminin and proteoglycans. In addition to sequence homology, all MMPs share the following characteristics: the catalytic mechanism is dependent upon a zinc ion at the active center, they cleave one or more extracellular matrix components, they are secreted as zymogens which are activated by removal of an ~10 kDa segment from the N-terminus and they are inhibited by tissue inhibitor of metalloproteinases (TIMP). These enzymes are involved in normal physiological processes such as embryogenesis and tissue remodeling and may play an important role in arthritis, periodontitis, and metastasis. MMP-2 (Gelatinase A, 72 kDa gelatinase, type IV collagenase, TBE-1) is synthesized as a 631 amino acid proenzyme (72 kDa zymogen) which is proteolytically processed at the first 80 amino acids to the 66 kDa active form. MMP-2, along with its most closely related member of the MMP family, MMP-9, show substrate specificity toward type IV and V collagens, gelatin and elastin. Numerous studies have shown a correlation between collagenase expression and metastatic potential and suggest that MMP-2 may be a useful marker for the diagnosis or prognosis of cancer.
          HostRabbit
          Immunogen speciesHuman
          Immunogenrecombinant, human pro-MMP-2
          IsotypeIgG
          Specieshuman, mouse
          Positive controlConditioned medium from HT-1080 cells or recombinant MMP-2
          FormLiquid
          FormulationIn 1X PBS, 0.2% BSA.
          Concentration Label Please refer to vial label for lot-specific concentration
          Preservative≤0.1% sodium azide
          CommentsThis antibody will cross-react with recombinant human MMP-9 at high concentrations of protein. No cross-reactivity seen with native MMP-9. Antibody should be titrated for optimal results in individual systems.
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFor long-term storage, aliquot and freeze (-20°C). Avoid freeze/thaw cycles.
          Toxicity Standard Handling
          ReferencesNikkari, S.T., et al. 1996. Am. J. Pathol. 149, 1427.
          Soini, Y., et al. 1994. J. Histochem. And Cytochemistry 42, 945.
          Autio-Harmainen, H., et al. 1993. Lab. Invest. 69, 312.
          Cottam, D.W. and Rees, R.C. 1993. Intl J. Oncol. 2, 861.
          Schnaper, H.W., et al. 1993. J. Cell. Physiol. 156, 235.
          Stetler-Stevenson, W.G., et al. 1993. FASEB J. 7, 1434.
          Autio-Harmainen, H., et al. 1992. Lab. Invest. 67, 191.
          Fridman, R., et al. 1992. J. Biol. Chem. 267, 15398.
          Margulies, I.M., et al. 1992. Cancer Epidemiology, Biomarkers and Prevention 1, 467.
          Woessner, J.F. 1991. FASEB J. 5, 2145.
          Liotta, L.A. and Stetler-Stevenson, W.G. 1990. in Seminars in Cancer Biology, ed. M.M. Gottesman. Vol. 1(2), 99.