MABN310 Anti-G-protein coupled receptor 56 (GPR56) Antibody, clone H11

MABN310
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M WB, ICC, IHC M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABN310
      DescriptionAnti-G-protein coupled receptor 56 (GPR56) Antibody, clone H11
      Alternate Names
      • G protein-coupled receptor 56
      • 7-transmembrane protein with no EGF-like N-terminal domains-1
      • Protein TM7XN1
      • G-protein coupled receptor 56
      Background InformationG-protein coupled receptor 56 (GPR56) is a ubiquitous adhesion receptor, which belongs to the G-protein coupled receptor 2 family and LN-TM7 subfamily. It is abundantly expressed in the in thyroid gland, brain, heart, and various tumor cells. Previous studies have suggested that GPR56 may inhibit the progression and metastasis of melanomas by interaction with extracellular-matrix proteins, such as Tissue Transglutaminase. GPR56 also plays a role in regulating VEGF production and angiogenesis via a PKCα-mediated pathway. GPR56 also plays a critical role in the development of the frontal cortex; previous studies have reported that mutations in GPR56 result in disorganized cortical lamination, which is most pronounced in the frontal cortex. This condition is known as bilateral frontoparietal polymicrogyria or BFPP.
      References
      Product Information
      FormatPurified
      Control
      • Brain tissue lysate from E13-E14 mouse
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationThis Anti-G-protein coupled receptor 56 (GPR56) Antibody, clone H11 is validated for use in Western Blotting, ICC, IHC for the detection of G-protein coupled receptor 56 (GPR56).
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A representative lot was used by an independent laboratory in E14.5 mouse brain tissue. (Luo, R., et al. (2011). Proc Natl Acad Sci U S A. 108(31):12925-12930.)

      Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in meningeal fibroblasts (MFs). (Luo, R., et al. (2011). Proc Natl Acad Sci U S A. 108(31):12925-12930.)
      Biological Information
      ImmunogenN-terminal fragment of mouse GPR56
      CloneH11
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Mouse
      Species Reactivity NoteDemonstrated to react with Mouse. Predicted to react with Human based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • GPR56
      • TM7XN1
      • TM7LN4
      • EGF-TM7-like
      • BFPP
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~62 kDa observed. Full-length GPR56 (GPR56FL) migrates at 75 kDa and the cleaved extracellular domain of GPR56 (GPR56ECD) migrates at 62 kDa. (J Biol Chem. 2008 May 23;283(21):14469-78).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in brain tissue lysate from E13-E14 mouse.

      Western Blot Analysis: 0.5 μg/mL of this antibody detected G-protein coupled receptor 56 in 10 µg of brain tissue lysate from E13-E14 mouse.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-G-protein coupled receptor 56 (GPR56) Antibody, clone H11 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-G-protein coupled receptor 56 (GPR56) Antibody, clone H11 Certificates of Analysis

      TitleLot Number
      Anti-G-protein coupled receptor 56 (GPR56), clone H112485981
      Anti-G-protein coupled receptor 56 (GPR56), clone H11 - 24580192458019
      Anti-G-protein coupled receptor 56 (GPR56), clone H11 - 25019392501939
      Anti-G-protein coupled receptor 56 (GPR56), clone H11 - Q2064897Q2064897
      Anti-G-protein coupled receptor 56 (GPR56), clone H11 -25901602590160
      Anti-G-protein coupled receptor 56 (GPR56), clone H11 -25937372593737
      Anti-G-protein coupled receptor 56 (GPR56), clone H11 -27037512703751
      Anti-G-protein coupled receptor 56 (GPR56), clone H11 -27389842738984
      Anti-G-protein coupled receptor 56 (GPR56), clone H11 -27566692756669
      Anti-G-protein coupled receptor 56 (GPR56), clone H11 -28918862891886

      References

      Reference overviewPub Med ID
      High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice.
      Rao, TN; Marks-Bluth, J; Sullivan, J; Gupta, MK; Chandrakanthan, V; Fitch, SR; Ottersbach, K; Jang, YC; Piao, X; Kulkarni, RN; Serwold, T; Pimanda, JE; Wagers, AJ
      Stem cell research  14  307-22  2015

      Show Abstract
      25840412 25840412
      G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination.
      Luo, Rong, et al.
      Proc. Natl. Acad. Sci. U.S.A., 108: 12925-30 (2011)  2011

      Show Abstract
      21768377 21768377

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies