MAB3077 Anti-G Protein Giα-2 Antibody, clone L5

MAB3077
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, Gp, H, M, R WB M Purified Monoclonal Antibody
      Description
      Catalogue NumberMAB3077
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-G Protein Giα-2 Antibody, clone L5
      References
      Product Information
      FormatPurified
      PresentationPurified immunoglobulin, in 0.02M phosphate buffer, 0.25M sodium chloride, pH 7.6, with 0.1% sodium azide.
      Applications
      ApplicationAnti-G Protein Giα-2 Antibody, clone L5 is an antibody against G Protein Giα-2 for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern blot 1:500 - 1:1000, with detection by 125I-labeled anti-IgG.

      Labels a single protein band of 39 - 42 kDa in bovine and rat membranes.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenRecombinant Gialpha-2, purified by the method of Linder (1990).
      CloneL5
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityGialpha-2. Strong reactivity with bovine (100%), mouse (69%), rat (69%), human (62%) and guinea pig (43%). Specificity confirmed by Western blot versus bovine Galphat, rat Goalpha, rat Gialpha-1, Gialpha-2, rat Gialpha-3, bovine Gsalpha, and murine GoalphaA and GoalphaB.
      IsotypeIgG2b
      Species Reactivity
      • Bovine
      • Guinea Pig
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • GNAI2
      • GNAI2B
      • WUGSC:H_LUCA15.1
      • H_LUCA15.1
      • H_LUCA16.1
      • GIP
      • WUGSC:H_LUCA16.1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P04899 # Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli.
      SIZE: 355 amino acids; 40451 Da
      SUBUNIT: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with GPSM1 (By similarity). Interacts with UNC5B.
      SIMILARITY: SwissProt: P04899 ## Belongs to the G-alpha family. G(i/o/t/z) subfamily.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-G Protein Giα-2 Antibody, clone L5 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-G Protein Giα-2 Antibody, clone L5 Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-Gi#945;#8722;2 MONOCLONAL ANTIBODY - 21277912127791
      MOUSE ANTI-Gia-2 MONOCLONAL ANTIBODY - 20259872025987
      MOUSE ANTI-Gia-2 MONOCLONAL ANTIBODY - 21658382165838
      MOUSE ANTI-Giα−2 MONOCLONAL ANTIBODY - 23911222391122
      MOUSE ANTI-Giα−2 - 32672903267290
      MOUSE ANTI-Giα−2 MONOCLONAL ANTIBODY2881021
      MOUSE ANTI-Giα−2 MONOCLONAL ANTIBODY3003761

      References

      Reference overviewPub Med ID
      A family of nonclassical class I MHC genes contributes to ultrasensitive chemodetection by mouse vomeronasal sensory neurons.
      Leinders-Zufall, T; Ishii, T; Chamero, P; Hendrix, P; Oboti, L; Schmid, A; Kircher, S; Pyrski, M; Akiyoshi, S; Khan, M; Vaes, E; Zufall, F; Mombaerts, P
      The Journal of neuroscience : the official journal of the Society for Neuroscience  34  5121-33  2014

      Show Abstract
      24719092 24719092
      Intracerebroventricular antisense knockdown of G alpha i2 results in ciliary stasis and ventricular dilatation in the rat.
      Mönkkönen, KS; Hakumäki, JM; Hirst, RA; Miettinen, RA; O'Callaghan, C; Männistö, PT; Laitinen, JT
      BMC neuroscience  8  26  2007

      Show Abstract Full Text Article
      17430589 17430589
      Chronic but not acute intracerebroventricular administration of amyloid beta-peptide(25-35) decreases somatostatin content, adenylate cyclase activity, somatostatin-induced inhibition of adenylate cyclase activity, and adenylate cyclase I levels in the rat hippocampus.
      E Burgos-Ramos,A Hervás-Aguilar,L Puebla-Jiménez,M C Boyano-Adánez,E Arilla-Ferreiro
      Journal of neuroscience research  85  2007

      Show Abstract
      17086550 17086550
      Hormonal regulation of Galphai2 and mPRalpha in immortalized human oviductal cell line OE-E6/E7.
      Mönkkönen, KS; Aflatoonian, R; Lee, KF; Yeung, WS; Tsao, SW; Laitinen, JT; Fazeli, A
      Molecular human reproduction  13  845-51  2007

      Show Abstract
      17977902 17977902
      Gly-Pro-Glu protects beta-amyloid-induced somatostatin depletion in the rat cortex.
      David Aguado-Llera, Mercedes Martín-Martínez, María Teresa García-López, Eduardo Arilla-Ferreiro, Vicente Barrios
      Neuroreport  15  1979-82  2004

      Show Abstract
      15305149 15305149
      Acutely administered melatonin decreases somatostatin-binding sites and the inhibitory effect of somatostatin on adenylyl cyclase activity in the rat hippocampus.
      Rosa María Izquierdo-Claros, María del Carmen Boyano-Adánez Md, Eduardo Arilla-Ferreiro
      Journal of pineal research  36  87-94  2004

      Show Abstract
      14962059 14962059
      Activity of the hippocampal somatostatinergic system following daily administration of melatonin.
      Rosa María Izquierdo-Claros, María Del Carmen Boyano-Adánez, Eduardo Arilla-Ferreiro
      Brain research. Molecular brain research  126  107-13  2004

      Show Abstract
      15249133 15249133
      Effects of subchronic and chronic melatonin treatment on somatostatin binding and its effects on adenylyl cyclase activity in the rat frontoparietal cortex.
      Rosa María Izquierdo-Claros, María del Carmen Boyano-Adánez, Eduardo Arilla-Ferreiro
      Journal of pineal research  33  189-97  2002

      Show Abstract
      12390500 12390500
      Acute modulation of somatostatin receptor function by melatonin in the rat frontoparietal cortex.
      R M Izquierdo-Claros, M C Boyano-Adánez, G Torrecillas, M Rodríguez-Puyol, E Arilla-Ferreiro
      Journal of pineal research  31  46-56  2001

      Show Abstract
      11485004 11485004
      The coupling of 5-oxo-eicosanoid receptors to heterotrimeric G proteins.
      O'Flaherty JT, Taylor JS, Kuroki M.
      Journal of immunology (Baltimore, Md. : 1950)  164  3345-52  2000

      Show Abstract
      10706729 10706729

      Data Sheet

      Title
      Anti-G Protein Gialpha-2, clone L5 - Data Sheet

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies