AB4068 Anti-G Protein Gβ5-D1 Antibody

AB4068
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M WB Rb Purified Polyclonal Antibody
      Description
      Catalogue NumberAB4068
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-G Protein Gβ5-D1 Antibody
      Background InformationThe Gbeta5 protein is a G protein subunit present predominantly in the central nervous system. This protein appears to be expressed in two forms, one found in the brain of 39 kDa and one found in the retina of 44 kDa. It has also been found that Gbeta5 associates tightly with RGS7, a member of the superfamily of negative regulators of G protein signaling. These complexes have been localized to most regions of the brain, whereas Gbeta1-4 exhibit no observable colocalization with RGS7, despite their widespread codistribution throughout similar neuronal networks. This antibody is specific for a peptide sequence within the D1 blade which is not found in Gbeta1-4.
      References
      Product Information
      FormatPurified
      Control
      • POSITIVE CONTROL: Plasma membranes from rat cerebrum.
      PresentationPurified immunoglobulin. Liquid in phosphate buffered saline with 0.08% sodium azide.
      Applications
      ApplicationThis Anti-G Protein Gβ5-D1 Antibody is validated for use in WB for the detection of G Protein Gβ5-D1.
      Key Applications
      • Western Blotting
      Application NotesWestern Blot (5-10 μg/ml)

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenUnique peptide sequence derived from the D1 blade of the Gbeta5protein.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes G protein subunit Gbeta5.
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryHeterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist.
      Gene Symbol
      • GNB5
      • FLJ37457
      • FLJ43714
      • Gbeta5
      • GB5
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O14775 # Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.
      SIZE: 395 amino acids; 43566 Da
      SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma. Component of the RGS9-1-Gbeta5 complex composed of RGS9 (isoform RGS9-1), Gbeta5 (GNB5) and RGS9BP (By similarity).
      TISSUE SPECIFICITY: Expressed in multiple tissues.
      SIMILARITY: SwissProt: O14775 ## Belongs to the WD repeat G protein beta family. & Contains 7 WD repeats.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-G Protein Gβ5-D1 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overviewPub Med ID
      Epigenetic changes by zebularine leading to enhanced differentiation of human promyelocytic leukemia NB4 and KG1 cells.
      Savickiene J, Treigyte G, Jonusiene V, Bruzaite R, Borutinskaite VV, Navakauskiene R
      Molecular and cellular biochemistry  359  245-61. Epub 2011 Aug 13.  2012

      Show Abstract
      21842375 21842375
      Homozygous loss of ADAM3A revealed by genome-wide analysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomas.
      Barrow J, Adamowicz-Brice M, Cartmill M, MacArthur D, Lowe J, Robson K, Brundler MA, Walker DA, Coyle B, Grundy R.
      Neuro-oncology  13  212-22  2011

      Show Abstract
      21138945 21138945

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies