ABE792 Anti-FAM120A Antibody

ABE792
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R WB, IHC, IF Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberABE792
      DescriptionAnti-FAM120A Antibody
      Alternate Names
      • Constitutive coactivator of PPAR-gamma-like protein 1
      • Oxidative stress-associated Src activator
      • Protein FAM120A
      Background InformationConstitutive coactivator of PPAR-gamma-like protein 1, also known as Oxidative stress-associated Src activator or Protein FAM120A, and encoded by the gene name FAM120A or OSSA, was recently detected within the Purα-containing mRNA-protein complex in the brain. As a novel RNA-binding protein, FAM120A is a critical component of the oxidative stress-induced survival signaling. It may participate in mRNA transport in the cytoplasm. FAM120A activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. FAM120A is highly expressed in scirrhous-type gastric cancer tissues compared with normal gastric mucosa. FAM120A protects cells from apoptosis through activation of SRKs in response to oxidative stress. Blocking of the survival signaling mediated by FAM120A, which sensitizes the cancer cells to stress-induced apoptosis, may be a novel therapeutic approach for gastric scirrhous carcinoma cells.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Applications
      ApplicationAnti-FAM120A Antibody is an antibody against FAM120A for use in western blotting, IHC & immunofluorescence.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunofluorescence
      Application NotesImmunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected FAM120A in rat brain tissue.

      Immunofluorescence Analysis: 20 μg/mL from a representative lot detected FAM120A in rat brain cells.
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide corresponding to the N-terminus of human FAM120A.
      EpitopeN-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody will not cross-reacti with FAM120B/PGCC1.
      Species Reactivity
      • Human
      • Rat
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • FAM120A
      • C9orf10
      • KIAA0183
      • OSSA
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~130 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in SK-N-SH cell lysate.

      Western Blotting Analysis: 0.5 μg/mL of this antibody detected FAM120A in SK-N-SH cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications