AB15468 Anti-Choline Acetyltransferase Antibody

AB15468
500 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M ICC, IHC Ch Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberAB15468
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Choline Acetyltransferase Antibody
      Alternate Names
      • ChAT
      References
      Product Information
      FormatAffinity Purified
      PresentationLiquid in PBS, pH 7.2 with 0.02% sodium azide.
      Applications
      ApplicationAnti-Choline Acetyltransferase Antibody is an antibody against Choline Acetyltransferase for use in IC, IH.
      Key Applications
      • Immunocytochemistry
      • Immunohistochemistry
      Application NotesImmunohistochemistry: 1:1,000-1:2,000 using 2% paraformaldehyde fixed tissue.

      Immunocytochemistry: 1:1,000-1:2,000 using 2% paraformaldehyde fixed cells.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic peptide corresponding to human/mouse ChAT protein.
      HostChicken
      SpecificityCholine acetyltransferase [ChAT]
      Species Reactivity
      • Mouse
      Species Reactivity NoteOther species have not yet been tested. It is expected that the antibody will also react with human due to immunogen sequence similarity.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryCholinergic systems are implicated in numerous neurologic functions. Alteration in some cholinergic neurons may account for the disturbances of Alzheimer disease. The protein encoded by this gene synthesizes the neurotransmitter acetylcholine. Alternative splice variants have been found that contain alternative 5' untranslated exons. Three of the four described splice variants encode identical 69 kDa proteins while one variant encodes both the 69 kDa and a larger 82 kDa protein.
      Gene Symbol
      • CHAT
      • ChAT
      • CMS1A2
      • CHOACTase
      • CMS1A
      • EC 2.3.1.6
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P28329 # Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
      SIZE: 748 amino acids; 82568 Da
      DISEASE: SwissProt: P28329 # Defects in CHAT are the cause of familial infantile myasthenia gravis 2 (FIMG2) [MIM:254210, 254200]; also known as CMS-EA. FIMG2 patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement. Inheritance is autosomal recessive.
      SIMILARITY: SwissProt: P28329 ## Belongs to the carnitine/choline acetyltransferase family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
      Packaging Information
      Material Size500 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Choline Acetyltransferase Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Choline Acetyltransferase Antibody Certificates of Analysis

      TitleLot Number
      CHICKEN ANTI-CHOLINE ACETYLTRANSFERASE (ChAT) POLYCLONAL ANTIBODY - 24419702441970
      CHICKEN ANTI-CHOLINE ACETYLTRANSFERASE (ChAT) POLYCLONAL ANTIBODY - 24467182446718
      CHICKEN ANTI-CHOLINE ACETYLTRANSFERASE (ChAT) POLYCLONAL ANTIBODY2924873
      CHICKEN ANTI-CHOLINE ACETYLTRANSFERASE (ChAT) POLYCLONAL ANTIBODY3124179
      CHICKEN ANTI-CHOLINE ACETYLTRANSFERASE (ChAT) POLYCLONAL ANTIBODY3156103
      CHICKEN ANTI-CHOLINE ACETYLTRANSFERASE (ChAT) POLYCLONAL ANTIBODY3011665
      CHICKEN ANTI-CHOLINE ACETYLTRANSFERASE (ChAT) POLYCLONAL ANTIBODY - 20172602017260
      CHICKEN ANTI-CHOLINE ACETYLTRANSFERASE (ChAT) POLYCLONAL ANTIBODY - 20372122037212
      CHICKEN ANTI-CHOLINE ACETYLTRANSFERASE (ChAT) POLYCLONAL ANTIBODY - 20386282038628
      CHICKEN ANTI-CHOLINE ACETYLTRANSFERASE (ChAT) POLYCLONAL ANTIBODY - 20660152066015

      References

      Reference overviewPub Med ID
      Atoh1-lineal neurons are required for hearing and for the survival of neurons in the spiral ganglion and brainstem accessory auditory nuclei.
      SM Maricich, A Xia, EL Mathes, VY Wang, JS Oghalai, B Fritzsch, HY Zoghbi
      The Journal of neuroscience : the official journal of the  29  11123-11133  2009

      Show Abstract Full Text Article
      19741118 19741118

      Data Sheet

      Title
      Anti-Choline Acetyltranferase - Data Sheet

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies