236002 | Anti-COX2, C-Terminal Rabbit pAb

236002
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityHostAntibody Type
      B, H, M, R, Sh Rb Polyclonal Antibody

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      236002-50UG
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          Plastic ampoule 50 μg
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          Description
          OverviewRecognizes COX2. Does not cross-react with COX1.
          Catalogue Number236002
          Brand Family Calbiochem®
          SynonymsAnti-Cyclooxygenase-2, Anti-PGHS-2, Anti-Prostaglandin H Synthase-2
          References
          ReferencesHla, T., and Neilson, K. 1992. Proc. Natl. Acad. Sci. USA 89, 7384.
          Product Information
          FormLiquid
          FormulationIn PBS, 0.1% BSA, pH 7.4.
          Preservative≤0.1% sodium azide
          Applications
          Key Applications Enzyme-Linked Immunosorbent Assay
          Immunoblotting (Western Blotting)
          Application NotesImmunoblotting (1-10 µg/ml, chemiluminescence)
          ELISA (1:10,000-1:100,000)
          Application CommentsDoes not cross-react with COX1. Variables associated with assay conditions will dictate the optimal working dilution.
          Biological Information
          Immunogena synthetic peptide corresponding to a 17-amino acid sequence near the C-terminus of human COX2
          ImmunogenHuman
          HostRabbit
          IsotypeIgG
          Species Reactivity
          • Bovine
          • Human
          • Mouse
          • Rat
          • Sheep
          Antibody TypePolyclonal Antibody
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          236002

          References

          Reference overview
          Hla, T., and Neilson, K. 1992. Proc. Natl. Acad. Sci. USA 89, 7384.

          Brochure

          Title
          Antibody Sourcebook!" Second Edition

          Technical Info

          Title
          Non-steroidal Cyclooxygenase (COX) Inhibitors
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-July-2007 RFH
          SynonymsAnti-Cyclooxygenase-2, Anti-PGHS-2, Anti-Prostaglandin H Synthase-2
          ApplicationImmunoblotting (1-10 µg/ml, chemiluminescence)
          ELISA (1:10,000-1:100,000)
          DescriptionImmunoaffinity purified rabbit polyclonal antibody. Recognizes the ~72 kDa COX2 protein.
          BackgroundCOX proteins are membrane-associated heme proteins that have cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID (Nonsteroidal anti-inflammatory drugs) such as aspirin. Prostaglandins (PGs) formed by the enzymatic activity of COX1 are primarily involved in the regulation of homeostatic functions throughout the body, whereas PGs formed by COX2 primarily mediate pain, fever, and inflammation. COX2 is induced by a wide variety of stimuli and was initially identified as an immediate-early growth response gene. In addition, COX2 expression is markedly increased in 85-90% of human colorectal adenocarcinomas, whereas COX1 levels remain unchanged. COX2 may be involved in angiogenesis, as new angiogenic endothelial cells express the inducible COX2 while normal blood vessels express COX1.
          HostRabbit
          Immunogen speciesHuman
          Immunogena synthetic peptide corresponding to a 17-amino acid sequence near the C-terminus of human COX2
          IsotypeIgG
          Speciesbovine, human, mouse, rat, sheep
          FormLiquid
          FormulationIn PBS, 0.1% BSA, pH 7.4.
          Concentration Label Please refer to vial label for lot-specific concentration
          Preservative≤0.1% sodium azide
          CommentsDoes not cross-react with COX1. Variables associated with assay conditions will dictate the optimal working dilution.
          Storage -20°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Standard Handling
          ReferencesHla, T., and Neilson, K. 1992. Proc. Natl. Acad. Sci. USA 89, 7384.