OP93 Anti-BRCA1 (Ab-2) Mouse mAb (MS13)

OP93
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityHostAntibody Type
      H M Monoclonal Antibody

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      OP93-100UG
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
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          Will advise
          Contact Customer Service
          Contact Customer Service

          Plastic ampoule 100 μg
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          Description
          OverviewRecognizes the ~220 kDa BRCA1 protein in MCF-7 cells. Does not react with blood group antigens or growth factor receptors such as EGFR. Sold under license of U.S. Patent 5,753,441 and 6,162,897.
          Catalogue NumberOP93
          Brand Family Calbiochem®
          SynonymsAnti-Breast Cancer Susceptibility Protein
          References
          ReferencesScully, R., et al. 1996. Science 272, 123.
          Gudas, J.M., et al. 1996. Cell Growth Differ. 7, 717.
          Vaughn, J.P., et al. 1996. Cell Growth Differ. 7, 711.
          Goldgar, D.E. and Reilly, P.R. 1995. Nat. Genet. 11, 113.
          Merajver, S.D., et al. 1995. Clin. Can. Res. 1, 539.
          Merajver, S.D., et al. 1995. Nat. Genet. 9, 439.
          Struewing, J.P., et al. 1995. Nat. Genet. 11, 198.
          Thompson, M.E., et al. 1995. Nat. Genet. 9, 444.
          Futreal, P.A., et al. 1994. Science 266, 120.
          Miki, Y., et al. 1994. Science 266, 66.
          Product Information
          DeclarationSold under license of U.S. Patents 5,753,441 and 6,162,897.
          FormLiquid
          FormulationIn 0.05 M sodium phosphate buffer, 0.2% gelatin.
          Positive controlMCF7 cells
          Preservative≤0.1% sodium azide
          Applications
          Application ReferencesImmunoblotting, Immunoprecipitation, Immunofluorescence, Paraffin Sections Scully, R., et al. 1996. Science 272, 123.
          Key Applications Paraffin Sections
          Immunoblotting (Western Blotting)
          Immunofluorescence
          Immunoprecipitation
          Application NotesImmunoblotting (2 µg/ml, chemiluminescence; see application references)
          Immunofluorescence (see application references)
          Immunoprecipitation (see application references)
          Paraffin Sections (see application references)
          Application CommentsAntibody should be titrated for optimal results in individual systems.
          Biological Information
          Immunogenrecombinant, human BRCA1
          ImmunogenHuman
          Epitopewithin amino acids 1-304
          CloneMS13
          HostMouse
          IsotypeIgG₁
          Species Reactivity
          • Human
          Antibody TypeMonoclonal Antibody
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Yes
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Anti-BRCA1 (Ab-2) Mouse mAb (MS13) SDS

          Title

          Safety Data Sheet (SDS) 

          Anti-BRCA1 (Ab-2) Mouse mAb (MS13) Certificates of Analysis

          TitleLot Number
          OP93

          References

          Reference overview
          Scully, R., et al. 1996. Science 272, 123.
          Gudas, J.M., et al. 1996. Cell Growth Differ. 7, 717.
          Vaughn, J.P., et al. 1996. Cell Growth Differ. 7, 711.
          Goldgar, D.E. and Reilly, P.R. 1995. Nat. Genet. 11, 113.
          Merajver, S.D., et al. 1995. Clin. Can. Res. 1, 539.
          Merajver, S.D., et al. 1995. Nat. Genet. 9, 439.
          Struewing, J.P., et al. 1995. Nat. Genet. 11, 198.
          Thompson, M.E., et al. 1995. Nat. Genet. 9, 444.
          Futreal, P.A., et al. 1994. Science 266, 120.
          Miki, Y., et al. 1994. Science 266, 66.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-October-2007 RFH
          SynonymsAnti-Breast Cancer Susceptibility Protein
          ApplicationImmunoblotting (2 µg/ml, chemiluminescence; see application references)
          Immunofluorescence (see application references)
          Immunoprecipitation (see application references)
          Paraffin Sections (see application references)
          DescriptionPurified mouse monoclonal antibody generated by immunizing mice with the specified iummunogen and fusing splenocytes with NS1 mouse myeloma cells. Recognizes the ~220 kDa BRCA1 protein.
          BackgroundInactivation of the BRCA1 gene, located at 17q21, is responsible for some forms of familial breast and ovarian cancer and sporadic ovarian cancer. BRCA1 encodes a protein of 1863 amino acids with an amino-terminal domain that exhibits similarity to the zinc-ring domain found in several regulatory and transcription factors. Mutations that disrupt this domain are some of the most frequently occurring ones linked to breast and ovarian cancer. Inhibition of BRCA1 expression leads to accelerated growth of mammary cells in vitro while loss of expression is observed during progression from benign disease to metastatic breast cancer suggesting that BRCA1 serves as a negative growth regulator. The ~220 kDa BRCA1 protein is expressed predominantly in the nucleus and appears to undergo cell cycle regulation with mRNA expression induced prior to DNA synthesis.
          HostMouse
          Immunogen speciesHuman
          Immunogenrecombinant, human BRCA1
          Epitopewithin amino acids 1-304
          CloneMS13
          IsotypeIgG₁
          Specieshuman
          Positive controlMCF7 cells
          FormLiquid
          FormulationIn 0.05 M sodium phosphate buffer, 0.2% gelatin.
          Concentration Label Please refer to vial label for lot-specific concentration
          Preservative≤0.1% sodium azide
          CommentsAntibody should be titrated for optimal results in individual systems.
          Storage +2°C to +8°C
          Do Not Freeze Yes
          Toxicity Standard Handling
          ReferencesScully, R., et al. 1996. Science 272, 123.
          Gudas, J.M., et al. 1996. Cell Growth Differ. 7, 717.
          Vaughn, J.P., et al. 1996. Cell Growth Differ. 7, 711.
          Goldgar, D.E. and Reilly, P.R. 1995. Nat. Genet. 11, 113.
          Merajver, S.D., et al. 1995. Clin. Can. Res. 1, 539.
          Merajver, S.D., et al. 1995. Nat. Genet. 9, 439.
          Struewing, J.P., et al. 1995. Nat. Genet. 11, 198.
          Thompson, M.E., et al. 1995. Nat. Genet. 9, 444.
          Futreal, P.A., et al. 1994. Science 266, 120.
          Miki, Y., et al. 1994. Science 266, 66.
          Application referencesImmunoblotting, Immunoprecipitation, Immunofluorescence, Paraffin Sections Scully, R., et al. 1996. Science 272, 123.