MABS102 Anti-Apolipoprotein H Antibody

MABS102
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, M WB, IHC M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABS102
      DescriptionAnti-Apolipoprotein H Antibody
      Alternate Names
      • Beta-2-glycoprotein 1
      • APC inhibitor
      • Activated protein C-binding protein
      • Anticardiolipin cofactor
      • Apolipoprotein H
      • Apo-H
        Beta-2-glycoprotein I
      • B2GPI
      • Beta(2)GPI
      Background InformationAlso known as Native β2-glycoprotein 1, Apolipoprotein H is a carbohydrate-rich plasma protein which is partially comprised of sialylated and galactosylated bi- and triantennary oligosaccharides and is expressed by the liver and secreted in plasma. It is reported that Apolipoprotein H is an initiating antigen that is required for antibody recognition and is also known to bind to anionic phospholipids. It is also suggested to play a role in lipid metabolism.
      References
      Product Information
      FormatPurified
      Control
      • Human liver tissue
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-Apolipoprotein H Antibody detects level of Apolipoprotein H & has been published & validated for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern Blot Analysis: 1 µg/mL from a representative lot detected Apolipoprotein H in human liver tissue lysate.
      Biological Information
      ImmunogenGST-Tagged-recombinant protein corresponding to human Apolioprotein H.
      Clone17D11.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      • Rat
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryApolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections.
      Gene Symbol
      • APOH
      • B2G1
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

      SUBCELLULAR LOCATION: Secreted.

      TISSUE SPECIFICITY: Expressed by the liver and secreted in plasma.
      Molecular Weight~45-50 kDa observed. A number of bands may be observed between a molecular weight of ~45-50 kDa due to heavy glycosolation in some tissues.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human liver tissue.

      Immunohistochemistry Analysis: A 1:2,000 dilution of this antibody detected Apolipoprotein H in human liver tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Apolipoprotein H Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Apolipoprotein H Antibody Certificates of Analysis

      TitleLot Number
      Anti-Apolipoprotein H - 21082472108247
      Anti-Apolipoprotein H - 21933462193346
      Anti-Apolipoprotein H - 22742972274297
      Anti-Apolipoprotein H - 24940992494099
      Anti-Apolipoprotein H - 25623932562393
      Anti-Apolipoprotein H - NRG1932582NRG1932582
      Anti-Apolipoprotein H -25472262547226
      Anti-Apolipoprotein H -25553292555329
      Anti-Apolipoprotein H -25770482577048
      Anti-Apolipoprotein H -26084852608485

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies