182690 | AhR Agonist V, VAF347 - Calbiochem

182690
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      182690-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable pyrimidinylphenylamine compound that directly and reversibly targets aryl hydrocarbon receptor (AhR) with high-affinity, and induces AhR signaling. Reported to act as an immunomodulator with anti-inflammatory properties. Potently suppresses IgE secretion in B-cells with an IC50 of ~2 nM, and inhibits dendritic cells-mediated T-cell proliferation and cytokine production. Further, decreases lung eosinophilia in B-cell-deficient mice, and allergic inflammation. Downregulates PU.1 transcription factor, and impairs human monocytes and Langerhans dendritic cells differentiation.
          Catalogue Number182690
          Brand Family Calbiochem®
          Synonyms(4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine
          References
          ReferencesPlatzer, B., et al. 2009. J. Immunol. 183, 66.
          Hauben, E., et al. 2008. Blood 118, 1214.
          Lawrence, B.P., et al. 2008. Blood 112, 1158.
          Ettmayer, P., et al. 2006. Am. J. Respir. Crit. Care Med. 173, 599.
          Product Information
          FormWhite solid
          Hill FormulaC₁₇H₁₁ClF₃N₃
          Chemical formulaC₁₇H₁₁ClF₃N₃
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          182690

          References

          Reference overview
          Platzer, B., et al. 2009. J. Immunol. 183, 66.
          Hauben, E., et al. 2008. Blood 118, 1214.
          Lawrence, B.P., et al. 2008. Blood 112, 1158.
          Ettmayer, P., et al. 2006. Am. J. Respir. Crit. Care Med. 173, 599.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision24-August-2012 JSW
          Synonyms(4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine
          DescriptionA cell-permeable pyrimidinylphenylamine compound that directly and reversibly targets aryl hydrocarbon receptor (AhR) with high-affinity, and induces AhR signaling. Reported to act as an immunomodulator with anti-inflammatory properties. Potently suppresses IgE secretion in B-cells with an IC50 of ~2 nM, and inhibits dendritic cells-mediated T-cell proliferation and cytokine production. Further, decreases lung eosinophilia in B-cell-deficient mice, and allergic inflammation. Downregulates PU.1 transcription factor, and impairs human monocytes and Langerhans dendritic cells differentiation.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₇H₁₁ClF₃N₃
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesPlatzer, B., et al. 2009. J. Immunol. 183, 66.
          Hauben, E., et al. 2008. Blood 118, 1214.
          Lawrence, B.P., et al. 2008. Blood 112, 1158.
          Ettmayer, P., et al. 2006. Am. J. Respir. Crit. Care Med. 173, 599.