203800 | Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 76939-46-3 - Calbiochem

203800
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₀H₁₀BrN₅O₆P · Na 76939-46-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      203800-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewCell-permeable cAMP analog that has greater resistance to phosphodiesterases than cAMP. Preferentially activates protein kinase A (PKA). Directly activates Epac, a Rap1 guanine-nucleotide exchange factor.
          Catalogue Number203800
          Brand Family Calbiochem®
          Synonyms8-Bromo-cAMP, Na
          References
          ReferencesKawasaki, H., et al. 1998. Science 282, 2275.
          de Rooij, J., et al. 1998. Nature 396, 474.
          Boyer, B., and Thiery, J.P. 1993. J. Cell Biol. 120, 767.
          Hei, Y.-J., et al. 1991. Mol. Pharmacol. 39, 233.
          Product Information
          CAS number76939-46-3
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₀H₁₀BrN₅O₆P · Na
          Chemical formulaC₁₀H₁₀BrN₅O₆P · Na
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationAdenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt, CAS 76939-46-3, is a cell-permeable cAMP analog with greater resistance to phosphodiesterases. Preferentially activates protein kinase A.
          Biological Information
          Primary TargetPKA
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid pH >8.5.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          203800

          References

          Reference overview
          Kawasaki, H., et al. 1998. Science 282, 2275.
          de Rooij, J., et al. 1998. Nature 396, 474.
          Boyer, B., and Thiery, J.P. 1993. J. Cell Biol. 120, 767.
          Hei, Y.-J., et al. 1991. Mol. Pharmacol. 39, 233.

          Brochure

          Title
          Nucleotides and Bases Technical Bulletin

          Citations

          Title
        • Michael J. Cross, et al. (2002) The Shb Adaptor Protein Binds to Tyrosine 766 in the FGFR-1 and Regulates the Ras/MEK/MAPK Pathway via FRS2 Phosphorylation in Endothelial Cells. Molecular Biology of the Cell 13, 2881-2893.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision21-May-2008 RFH
          Synonyms8-Bromo-cAMP, Na
          DescriptionCell-permeable cAMP analog that is more resistant to phosphodiesterases than cAMP. Preferentially activates cAMP-dependent protein kinase (PKA). Induces the guanine-nucleotide-exchange factor activity of GEFI, also known as Epac (exchange protein directly activated by cAMP), and GEFII toward Rap1 both in vivo and in vitro.
          FormWhite solid
          CAS number76939-46-3
          Chemical formulaC₁₀H₁₀BrN₅O₆P · Na
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityH₂O
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid pH >8.5.
          Toxicity Standard Handling
          ReferencesKawasaki, H., et al. 1998. Science 282, 2275.
          de Rooij, J., et al. 1998. Nature 396, 474.
          Boyer, B., and Thiery, J.P. 1993. J. Cell Biol. 120, 767.
          Hei, Y.-J., et al. 1991. Mol. Pharmacol. 39, 233.
          Citation
        • Michael J. Cross, et al. (2002) The Shb Adaptor Protein Binds to Tyrosine 766 in the FGFR-1 and Regulates the Ras/MEK/MAPK Pathway via FRS2 Phosphorylation in Endothelial Cells. Molecular Biology of the Cell 13, 2881-2893.