190080 AY 9944 - CAS 366-93-8 - Calbiochem

190080
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₂H₂₈Cl₂N₂ • 2HCl 366-93-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      190080-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable amphiphilic diamine that blocks cholesterol biosynthesis and its esterification. Specifically blocks 7-dehydrocholesterol reductase (Δ7-sterol reductase) activity with IC50= 13 nM. Important tool in Sonic Hedgehog signaling and teratogenicity studies. Also reported to induce a rapid and irreversible reduction in Acidic-Sphingomyelinase activity in fibroblasts.
          Catalogue Number190080
          Brand Family Calbiochem®
          Synonymstrans-1,4-bis(2-Chlorobenzylaminomethyl)cyclohexane, 2HCl, Shh Signaling Antagonist IV
          References
          ReferencesGofflot, F., et al. 2001. Dev. Dyn. 220, 99.
          Cooper, M.K., et al. 1998. Science 280, 1603.
          Incardona, J.P., et al. 1998. Development 125, 3553.
          Moebius, F.F., et al. 1998. Proc. Natl. Acad. Sci. USA95, 1899.
          Yoshida, Y. 1985. J. Biochem. 98, 1669.
          Kraml, M., et al. 1964. Biochem. Biophys. Res. Commun. 15, 455.
          Product Information
          CAS number366-93-8
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₂H₂₈Cl₂N₂ • 2HCl
          Chemical formulaC₂₂H₂₈Cl₂N₂ • 2HCl
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Target7-dehydrocholesterol reductase (δ7-sterol reductase)
          Primary Target IC<sub>50</sub>13 nM in blocking 7-dehydrocholesterol reductase (δ7-sterol reductase) activity
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSGU7025000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful & Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          190080

          References

          Reference overview
          Gofflot, F., et al. 2001. Dev. Dyn. 220, 99.
          Cooper, M.K., et al. 1998. Science 280, 1603.
          Incardona, J.P., et al. 1998. Development 125, 3553.
          Moebius, F.F., et al. 1998. Proc. Natl. Acad. Sci. USA95, 1899.
          Yoshida, Y. 1985. J. Biochem. 98, 1669.
          Kraml, M., et al. 1964. Biochem. Biophys. Res. Commun. 15, 455.

          Brochure

          Title
          Calbiochem Biologics 32.1
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-October-2007 JSW
          Synonymstrans-1,4-bis(2-Chlorobenzylaminomethyl)cyclohexane, 2HCl, Shh Signaling Antagonist IV
          DescriptionA cell-permeable, amphiphilic diamine that acts as a potent inhibitor of cholesterol biosynthesis and esterification and exhibits teratogenic properties. Specifically blocks 7-dehydro-cholesterol reductase (Δ7-sterol reductase; DHC) activity with IC50= 13 nM. Reported to disrupt Sonic Hedgehog (Shh) signaling during embryogenesis in rats. Also reported to induce a rapid and irreversible reduction in acidic-sphingomyelinase activity in fibroblasts.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number366-93-8
          RTECSGU7025000
          Chemical formulaC₂₂H₂₈Cl₂N₂ • 2HCl
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityH₂O (20 mg/ml) or DMSO (20 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful & Carcinogenic / Teratogenic
          ReferencesGofflot, F., et al. 2001. Dev. Dyn. 220, 99.
          Cooper, M.K., et al. 1998. Science 280, 1603.
          Incardona, J.P., et al. 1998. Development 125, 3553.
          Moebius, F.F., et al. 1998. Proc. Natl. Acad. Sci. USA95, 1899.
          Yoshida, Y. 1985. J. Biochem. 98, 1669.
          Kraml, M., et al. 1964. Biochem. Biophys. Res. Commun. 15, 455.