171260 AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem

171260
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₄H₂₅N₅O 866405-64-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      171260-10MG
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          Plastic ampoule 10 mg
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          171260-1MG
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              Plastic ampoule 1 mg
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              171260-5MG
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                  Plastic ampoule 5 mg
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                  Description
                  OverviewA cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50 = 25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFβR-I, ZAPK, Syk, PKCθ, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100 = 2.5 µM) and VEGF signaling-dependent intersomitic vessel formation (EC50 = 5 µM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR (Cat. No. 123040) and/or Metformin (Cat. No. 317240) for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo. Also available as a 10 mM solution in DMSO (Cat. No. 171261).
                  Catalogue Number171260
                  Brand Family Calbiochem®
                  Synonyms6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine, Dorsomorphin, AMPK Inhibitor I, BMP Inhibitor I
                  References
                  ReferencesHao, J., et al. 2010. ACS Chem.Biol. 5, 245.
                  Yu, P.B., et al. 2008. Nat. Chem. Biol 4, 33.
                  Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
                  Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
                  Inoki, K., et al. 2003. Cell 115, 577.
                  Fryer, L.G., 2002. FEBS Lett. 531, 189.
                  Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.
                  Product Information
                  CAS number866405-64-3
                  ATP CompetitiveY
                  FormLight yellow solid
                  Hill FormulaC₂₄H₂₅N₅O
                  Chemical formulaC₂₄H₂₅N₅O
                  ReversibleY
                  Structure formula ImageStructure formula Image
                  Applications
                  Biological Information
                  Primary TargetAMPK
                  Primary Target IC<sub>50</sub>25.1, 148, and 234.6 nM, against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity, respectively
                  Primary Target K<sub>i</sub>EC100 = 2.5 µM against BMP pathway-dependent dorsoventral development; EC50 = 5 µM against VEGF signaling-dependent intersomitic vessel formation in zebrafish embryo in vivo
                  Purity≥95% by HPLC
                  Physicochemical Information
                  Cell permeableY
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  Safety Information
                  Product Usage Statements
                  Storage and Shipping Information
                  Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
                  Toxicity Standard Handling
                  Storage +2°C to +8°C
                  Protect from Light Protect from light
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
                  Packaging Information
                  Packaged under inert gas Packaged under inert gas
                  Transport Information
                  Supplemental Information
                  Specifications

                  Documentation

                  SDS

                  Title

                  Safety Data Sheet (SDS) 

                  Certificates of Analysis

                  TitleLot Number
                  171260

                  References

                  Reference overview
                  Hao, J., et al. 2010. ACS Chem.Biol. 5, 245.
                  Yu, P.B., et al. 2008. Nat. Chem. Biol 4, 33.
                  Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
                  Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
                  Inoki, K., et al. 2003. Cell 115, 577.
                  Fryer, L.G., 2002. FEBS Lett. 531, 189.
                  Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.

                  Brochure

                  Title
                  Calbiochem Biologics 32.1
                  New Research Tools for Signal Transduction and Life Science Research
                  Data Sheet

                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                  Revision22-March-2012 JSW
                  Synonyms6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine, Dorsomorphin, AMPK Inhibitor I, BMP Inhibitor I
                  DescriptionA cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50 = 25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFβR-I, ZAPK, Syk, PKCθ, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100 = 2.5 µM) and VEGF signaling-dependent intersomitic vessel formation (EC50 = 5 µM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR (Cat. No. 123040) and/or Metformin (Cat. No. 317240) for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo. Also available as a 10 mM solution in DMSO (Cat. No. 171261).
                  FormLight yellow solid
                  Intert gas (Yes/No) Packaged under inert gas
                  CAS number866405-64-3
                  Chemical formulaC₂₄H₂₅N₅O
                  Structure formulaStructure formula
                  Purity≥95% by HPLC
                  SolubilityDMSO (4 mg/ml), 2% HCl (10 mg/ml), 2% Acetic Acid (10 mg/ml), or Methanol (3 mg/ml)
                  Storage +2°C to +8°C
                  Protect from light
                  Do Not Freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
                  Toxicity Standard Handling
                  ReferencesHao, J., et al. 2010. ACS Chem.Biol. 5, 245.
                  Yu, P.B., et al. 2008. Nat. Chem. Biol 4, 33.
                  Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
                  Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
                  Inoki, K., et al. 2003. Cell 115, 577.
                  Fryer, L.G., 2002. FEBS Lett. 531, 189.
                  Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.