533464 AMPK Activator, COH-SR4 - Calbiochem

533464
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₃H₈Cl₄N₂O

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.33464.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell permeable, orally bioavailable bis(dichlorophenyl)urea that acts as an AMPK activator via possibly targeting upstream of AMPK. Shown to increase AMPK phosphorylation and activation in multiple preadipocytes and cancer cell lines dose-dependently. Inhibits glutathione S transferase (GST) activity and induces G2/M phase cell cycle arrest in multiple melanoma cells (IC50 = 5-11 µM). Effectively inhibits tumor burden, decreases angiogenesis marker CD31 and proliferation marker Ki67, and increases pAMPK levels in vivo (4 mg/kg p.o., mouse) without obvious toxicity. Displays similar anti-cancer effects in lung cancer models both in vitro and in vivo. In addition, shown to down-regulate key proteins involved in fatty acid synthesis and inhibits adipocyte differentiation via AMPK activation in 3T3-L1 obesity model cells (IC50 = ~1.5 µM).

          Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
          Catalogue Number533464
          Brand Family Calbiochem®
          SynonymsSR4
          References
          ReferencesSinghal, S. S., et al. 2013. Biochem. Pharm. 86, 1664.
          Figarola, J. L., et al. 2013. Int. J. Mol. Med. 31, 1166.
          Singhal, S. S., et al. 2012. Biochem. Pharm. 84, 1419.
          Product Information
          FormOff-white solid
          Hill FormulaC₁₃H₈Cl₄N₂O
          Chemical formulaC₁₃H₈Cl₄N₂O
          ReversibleY
          Applications
          Biological Information
          Primary Target IC<sub>50</sub>5-11 µ
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          AMPK Activator, COH-SR4 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Singhal, S. S., et al. 2013. Biochem. Pharm. 86, 1664.
          Figarola, J. L., et al. 2013. Int. J. Mol. Med. 31, 1166.
          Singhal, S. S., et al. 2012. Biochem. Pharm. 84, 1419.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-November-2015 JSW
          SynonymsSR4
          DescriptionA cell permeable, orally bioavailable bis(dichlorophenyl)urea that acts as an AMPK activator via possibly targeting upstream of AMPK. Shown to increase AMPK phosphorylation and activation in multiple preadipocytes and cancer cell lines dose-dependently. Inhibits glutathione S transferase (GST) activity and induces G2/M phase cell cycle arrest in multiple melanoma cells (IC50 = 5-11 µM). Effectively inhibits tumor burden, decreases angiogenesis marker CD31 and proliferation marker Ki67, and increases pAMPK levels in vivo (4 mg/kg p.o., mouse) without obvious toxicity. Displays similar anti-cancer effects in lung cancer models both in vitro and in vivo. In addition, shown to down-regulate key proteins involved in fatty acid synthesis and inhibits adipocyte differentiation via AMPK activation in 3T3-L1 obesity model cells (IC50 = ~1.5 µM).
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₃H₈Cl₄N₂O
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesSinghal, S. S., et al. 2013. Biochem. Pharm. 86, 1664.
          Figarola, J. L., et al. 2013. Int. J. Mol. Med. 31, 1166.
          Singhal, S. S., et al. 2012. Biochem. Pharm. 84, 1419.