126920 ALDH2 Agonist, Alda-1 - CAS 349438-38-6 - Calbiochem

126920
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₁Cl₂NO₃ 349438-38-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      126920-25MG
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          Plastic ampoule 25 mg
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          Description
          OverviewA cell-permeable benzamide compound that selectively enhances the activity of both the wild-type ALDH2*1 and the east asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (2.1-, 2.2, and 11-fold activation of 20 µg wt homo, wt/mut hetero, and mut homo tetramer, respectively, at 100 µM), while exhibiting no effect toward alcohol dehydrogenase 1, cytosolic ALDH1, or mitochondrial ALDH5. Both PKCε activatior- and ethanol-mediated protections against heart tissue ischemic damage are reported to correlate well with ALDH2 activation, and Alda-1, likewise, is shown to protect against ischemic tissue damage to excised rat hearts (26% and 24% reduction in infarct size and CPK release, respectively; 20 µM) ex vivo and anesthetized live rats (60% infarction reduction; 8.5 mg/kg) in vivo.
          Catalogue Number126920
          Brand Family Calbiochem®
          SynonymsN-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide
          References
          ReferencesChen, C.H., et al. 2008. Science 321, 1493.
          Product Information
          CAS number349438-38-6
          DeclarationPatent pending.
          FormOff-white solid
          Hill FormulaC₁₅H₁₁Cl₂NO₃
          Chemical formulaC₁₅H₁₁Cl₂NO₃
          Structure formula ImageStructure formula Image
          Applications
          ApplicationALDH2 Agonist, Alda-1, CAS 349438-38-6, is a cell-permeable, selective enhancer the activity of both the wild-type ALDH2*1 and the East Asian E487K mutant ALDH2*2 forms of mitochondrial ALDH2.
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing, reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          126920

          References

          Reference overview
          Chen, C.H., et al. 2008. Science 321, 1493.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-March-2014 JSW
          SynonymsN-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide
          DescriptionA cell-permeable benzamide compound that selectively enhances the activity of both the wild-type ALDH2*1 and the east asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (2.1-, 2.2, and 11-fold activation of 20 µg wt homo, wt/mut hetero, and mut homo tetramer, respectively, at 100 µM), while exhibiting no effect toward alcohol dehydrogenase 1, cytosolic ALDH1, or mitochondrial ALDH5. Both PKCε activatior- and ethanol-mediated protections against heart tissue ischemic damage are reported to correlate well with ALDH2 activation, and Alda-1, likewise, is shown to protect against ischemic tissue damage to excised rat hearts (26% and 24% reduction in infarct size and CPK release, respectively; 20 µM) ex vivo and anesthetized live rats (60% infarction reduction; 8.5 mg/kg) in vivo.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number349438-38-6
          Chemical formulaC₁₅H₁₁Cl₂NO₃
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (100 mg/ml) or Ethanol (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing, reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesChen, C.H., et al. 2008. Science 321, 1493.