123855 | AKR1C3 Inhibitor - Calbiochem

123855
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₄H₁₀F₃NO₂

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      123855-25MG
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          Glass bottle 25 mg
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          Description
          OverviewA cell-permeable 3-phenyl-aminobenzoate compound that acts as a potent, competitive, reversible, active-site targeting inhibitor of aldo-keto reductase 1C3 (AKR1C3; type 5 17β-hydroxysteroid dehydrogenase) (IC50 = 60 nM) with excellent selectivity over other closely related human AKR isoforms (IC50 = 22.7, 15.4, 62.7, >50, and >50 µM for and AKR1C1, AKR1C2, AKR1C4, AKR1B1 and AKR1B10, respectively. Exhibits a weak inhibitory effect on cyclooxygenase 1 and 2 (IC50 = 100 µM). Shown to efficiently block the AKR1C3-mediated production of testosterone in LNCaP-AKR1C3 cells (~10 µM).
          Catalogue Number123855
          Brand Family Calbiochem®
          Synonyms3-(4-(Trifluoromethyl)phenylamino)benzoic acid
          References
          ReferencesAdeniji, A.O., et al. 2012. J. Med. Chem. 55, 2311.
          Adeniji, A.O., et al. 2011. Bioorg. Med. Chem. Lett. 21,1464.
          Product Information
          FormWhite powder
          Hill FormulaC₁₄H₁₀F₃NO₂
          Chemical formulaC₁₄H₁₀F₃NO₂
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          123855

          References

          Reference overview
          Adeniji, A.O., et al. 2012. J. Med. Chem. 55, 2311.
          Adeniji, A.O., et al. 2011. Bioorg. Med. Chem. Lett. 21,1464.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-July-2012 JSW
          Synonyms3-(4-(Trifluoromethyl)phenylamino)benzoic acid
          DescriptionA cell-permeable 3-phenyl-aminobenzoate compound that acts as a potent, competitive, reversible, active-site targeting inhibitor of aldo-keto reductase 1C3 (AKR1C3; type 5 17β-hydroxysteroid dehydrogenase) (IC50 = 60 nM) with excellent selectivity over other closely related human AKR isoforms (IC50 = 22.7, 15.4, 62.7, >50, and >50 µM for and AKR1C1, AKR1C2, AKR1C4, AKR1B1 and AKR1B10, respectively. Exhibits a weak inhibitory effect on cyclooxygenase 1 and 2 (IC50 = 100 µM). Shown to efficiently block the AKR1C3-mediated production of testosterone in LNCaP-AKR1C3 cells (~10 µM).
          FormWhite powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₄H₁₀F₃NO₂
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesAdeniji, A.O., et al. 2012. J. Med. Chem. 55, 2311.
          Adeniji, A.O., et al. 2011. Bioorg. Med. Chem. Lett. 21,1464.