658408 AG 490, m-CF₃ - CAS 581797-29-7 - Calbiochem

658408
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service
      View Pricing & Availability

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₁₃F₃N₂O₃ 581797-29-7

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      658408-10MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Plastic ampoule 10 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA cell-permeable, reversible, substrate competitive, m-trifluoromethyl derivative of AG 490 (Cat. No. 658401) that displays apoptotic and antiproliferative properties (IC50 = 1.7 µM, 2.8 µM and 6.1 µM in 2E8, Baf/3 and Jurkat cells, respectively). Shown to inhibit IL-7-induced JAK3 tyrosine phosphorylation in 2E8 cells in vitro and significantly reduce lymph node cellularity in a murine B and T cell lymphoma model (1 mg per animal, i.p.) in vivo.
          Catalogue Number658408
          Brand Family Calbiochem®
          SynonymsNSC D722757, α-Cyano-(3,4-dihydroxy)-N-(m-trifluoromethyl)benzylcinnamide, 5H4
          References
          ReferencesGu, L., et al. 2005. Bioorg. Med. Chem. 13, 4269.
          Product Information
          CAS number581797-29-7
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₈H₁₃F₃N₂O₃
          Chemical formulaC₁₈H₁₃F₃N₂O₃
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetapoptotic and antiproliferative properties
          Primary Target IC<sub>50</sub>1.7 µM, 2.8 µM and 6.1 µM for displaying apoptotic and antiproliferative properties in 2E8, Baf/3 and Jurkat cells, respectively
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          AG 490, m-CF₃ - CAS 581797-29-7 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          AG 490, m-CF₃ - CAS 581797-29-7 - Calbiochem Certificates of Analysis

          TitleLot Number
          658408

          References

          Reference overview
          Gu, L., et al. 2005. Bioorg. Med. Chem. 13, 4269.

          Citations

          Title
        • Yona Goldshmit, et al. (2004) SOCS2 Induces Neurite Outgrowth by Regulation of Epidermal Growth Factor Receptor Activation. Journal of Biological Chemistry 279, 16349-16355.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-April-2011 RFH
          SynonymsNSC D722757, α-Cyano-(3,4-dihydroxy)-N-(m-trifluoromethyl)benzylcinnamide, 5H4
          DescriptionA cell-permeable, reversible, substrate competitive, m-trifluoromethyl derivative of AG 490 (Cat. No. 658401) that displays apoptotic and antiproliferative properties (IC50 = 1.7 µM, 2.8 µM and 6.1 µM in 2E8, Baf/3 and Jurkat cells, respectively). Shown to inhibit IL-7-induced JAK3 tyrosine phosphorylation in 2E8 cells in vitro and significantly reduce lymph node cellularity in a murine B and T cell lymphoma model (1 mg per animal, i.p.) in vivo.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number581797-29-7
          Chemical formulaC₁₈H₁₃F₃N₂O₃
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (0.5 mg/ml) or Methanol
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.
          Toxicity Standard Handling
          ReferencesGu, L., et al. 2005. Bioorg. Med. Chem. 13, 4269.
          Citation
        • Yona Goldshmit, et al. (2004) SOCS2 Induces Neurite Outgrowth by Regulation of Epidermal Growth Factor Receptor Activation. Journal of Biological Chemistry 279, 16349-16355.