565765 γ₄₀-Secretase Inhibitor I - Calbiochem

565765
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₃H₃₄N₂O₅

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      565765-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA potent, cell-permeable, reversible γ-secretase inhibitor that preferentially appears to inhibit the secretion of Aβ1-40 (>90%) over Aβ1-42 (~15%). Aβtotal IC50 ~ 15 µM; Aβ1-40 IC50 ~ 22 µM; Aβ1-42 IC50 > 50 µM in CHO cells stable transfected with the cDNA encoding βAPP695. Reported to be about 10-fold more potent than Z-Val-Phe-CHO (MDL 28170; Cat. No. 208722).
          Catalogue Number565765
          Brand Family Calbiochem®
          Synonymst-3,5-DMC-IL-CHO, N-trans-3,5-Dimethoxycinnamoyl)-Ile-leucinal
          References
          ReferencesHigaki, J.N., et al. 1999. J. Med. Chem. 42, 3889.
          Product Information
          ATP CompetitiveN
          FormWhite lyophilized solid
          Hill FormulaC₂₃H₃₄N₂O₅
          Chemical formulaC₂₃H₃₄N₂O₅
          ReversibleY
          Applications
          Biological Information
          Primary Targetsecretion of Aβ₁₋₄₀
          Primary Target IC<sub>50</sub>~ 15 µM for Aβtotal; ~ 22 µM for Aβ1-40; < 50 µM for Aβ1-42 in CHO cells stable transfected with the cDNA encoding βAPP695
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide Sequencetrans-3,5-DMC-Ile-Leu-CHO (DMC = Dimethoxycinnamoyl)
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          γ₄₀-Secretase Inhibitor I - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          γ₄₀-Secretase Inhibitor I - Calbiochem Certificates of Analysis

          TitleLot Number
          565765

          References

          Reference overview
          Higaki, J.N., et al. 1999. J. Med. Chem. 42, 3889.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-September-2008 RFH
          Synonymst-3,5-DMC-IL-CHO, N-trans-3,5-Dimethoxycinnamoyl)-Ile-leucinal
          DescriptionA potent, cell-permeable, reversible inhibitor of γ-secretase that is reported to preferentially inhibit the secretion of Aβ1-40 (>90%) vs. Aβ1-42. IC50 = ~15 µM for Aβtotal; ~22 µM for Aβ1-40; and >50 µM for Aβ1-42 in CHO cells stably transfected with the cDNA encoding βAPP695. Reported to be about 10-fold more potent than Z-Val-Phe-CHO [MDL 28170 (Cat. No. 208722)].
          FormWhite lyophilized solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₃H₃₄N₂O₅
          Peptide Sequencetrans-3,5-DMC-Ile-Leu-CHO (DMC = Dimethoxycinnamoyl)
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesHigaki, J.N., et al. 1999. J. Med. Chem. 42, 3889.