538916 16,16-Dimethyl Prostaglandin E2 - CAS 39746-25-3 - Calbiochem

538916
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      Overview

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      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      538916-1MG
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          1 mg
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          Description
          OverviewA cell-permeable and orally available synthetic PGE2 (Cat. No. 538904) 16,16-dimethyl derivative that exhibits similar biological activity as PGE2 as an EP receptor agonist both in in vitro and in in vivo, while being more resistant to PGDH metabolism. Shown to amplify wnt activity through cAMP/PKA-mediated regulation of cellular β-catenin protein stability during vertebrate development and organ regeneration.
          Catalogue Number538916
          Brand Family Calbiochem®
          Synonyms9-Oxo-11α,15R-dihydroxy-16,16-dimethyl-prosta-5Z,13E-dien-1-oic acid, dmPGE2
          References
          ReferencesGoessling, W., et al. 2009. Cell 136, 1136.
          Fitzgerald, J., et al. 2000. Endocrinology 141, 291.
          Coleman, R.A., et al. 1994. Pharmacol. Rev. 46, 205.
          Product Information
          CAS number39746-25-3
          FormLiquid
          FormulationSupplied as a solution in methylacetate (1 mg/100 µL)
          Hill FormulaC₂₂H₃₆O₅
          Chemical formulaC₂₂H₃₆O₅
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 11-36-66-67

          Highly flammable.
          Irritating to eyes.
          Repeated exposure may cause skin dryness or cracking.
          Vapors may cause drowsiness and dizziness.
          S PhraseS: 16-2-26-29-33

          Keep away from sources of ignition - No Smoking.
          Keep out of the reach of children.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Do not empty into drains.
          Take precautionary measures against static discharges.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Flammable
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage ≤ -70°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution in DMSO or EtOH store at ≤-70°C for up to 6 months; Store aqueous solutions on ice and use within 12 hrs.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          16,16-Dimethyl Prostaglandin E2 - CAS 39746-25-3 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          16,16-Dimethyl Prostaglandin E2 - CAS 39746-25-3 - Calbiochem Certificates of Analysis

          TitleLot Number
          538916

          References

          Reference overview
          Goessling, W., et al. 2009. Cell 136, 1136.
          Fitzgerald, J., et al. 2000. Endocrinology 141, 291.
          Coleman, R.A., et al. 1994. Pharmacol. Rev. 46, 205.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision18-May-2010 RFH
          Synonyms9-Oxo-11α,15R-dihydroxy-16,16-dimethyl-prosta-5Z,13E-dien-1-oic acid, dmPGE2
          DescriptionA cell-permeable and orally available synthetic PGE2 (Cat. No. 538904) 16,16-dimethyl derivative that exhibits similar biological activity as PGE2 as an EP receptor agonist both in in vitro and in in vivo, while being more resistant to PGDH metabolism. Shown to amplify wnt activity through cAMP/PKA-mediated regulation of cellular β-catenin protein stability during vertebrate development and organ regeneration.
          FormLiquid
          FormulationSupplied as a solution in methylacetate (1 mg/100 µL)
          Intert gas (Yes/No) Packaged under inert gas
          CAS number39746-25-3
          Chemical formulaC₂₂H₃₆O₅
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (100 mg/ml), EtOH (100 mg/ml), PBS, pH 7.2 (5 mg/ml). Gently blow away methylacetate under a stream of N2, and solubilize in either DMSO or EtOH purged with an inert gas.
          Storage ≤ -70°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution in DMSO or EtOH store at ≤-70°C for up to 6 months; Store aqueous solutions on ice and use within 12 hrs.
          Toxicity Flammable
          ReferencesGoessling, W., et al. 2009. Cell 136, 1136.
          Fitzgerald, J., et al. 2000. Endocrinology 141, 291.
          Coleman, R.A., et al. 1994. Pharmacol. Rev. 46, 205.