219334 | β-Catenin/Tcf Inhibitor V, BC21 - CAS 691005-38-6 - Calbiochem

219334
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₂H₃₆Cl₂Cu₂N₂O₂ 691005-38-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      219334-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable dimeric copper complex that competitively binds β-catenin and disrupts β-catenin/Tcf4 interaction reversibly (IC50 = 5.0 µM), and acts as a Wnt signaling inhibitor. Shown to induce preferential growth arrest in β-catenin overexpressing HCT116 colon cancer and HEK293 cells (≤ 10 µM), and downregulate mRNA expressions of c-Myc and cyclin D1. Reported to inhibit PP2C and proteasomal activities at higher concentrations (~50 µM).
          Catalogue Number219334
          Brand Family Calbiochem®
          SynonymsCopper, di-µ-chlorobis[1-[(1-piperidinyl-κN)methyl]-2-naphthalenolato-κO]di-(9Cl), Wnt Pathway Inhibitor XV
          References
          ReferencesTian, W., et al. 2012. Biochemistry 51, 724.
          Rogers, J.P., et al. 2006. J. Med. Chem. 49, 1658.
          Daniel, K.G., et al. 2004. Biochem. Pharmacol. 67, 1139.
          Product Information
          CAS number691005-38-6
          FormDark brown solid
          Hill FormulaC₃₂H₃₆Cl₂Cu₂N₂O₂
          Chemical formulaC₃₂H₃₆Cl₂Cu₂N₂O₂
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by Elemental Analysis
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot, freeze (≥-70°C). Stock solutions are stable for up to 12 months at ≥-70°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Certificates of Analysis

          TitleLot Number
          219334

          References

          Reference overview
          Tian, W., et al. 2012. Biochemistry 51, 724.
          Rogers, J.P., et al. 2006. J. Med. Chem. 49, 1658.
          Daniel, K.G., et al. 2004. Biochem. Pharmacol. 67, 1139.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-February-2017 JSW
          SynonymsCopper, di-µ-chlorobis[1-[(1-piperidinyl-κN)methyl]-2-naphthalenolato-κO]di-(9Cl), Wnt Pathway Inhibitor XV
          DescriptionA cell-permeable dimeric copper complex that competitively binds β-catenin and disrupts β-catenin/Tcf4 interaction reversibly (IC50 = 5.0 µM), and acts as a Wnt signaling inhibitor. Shown to induce preferential growth arrest in β-catenin overexpressing HCT116 colon cancer and HEK293 cells (≤ 10 µM), and downregulate mRNA expressions of c-Myc and cyclin D1. Reported to inhibit PP2C and proteasomal activities at higher concentrations (~50 µM).
          FormDark brown solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number691005-38-6
          Chemical formulaC₃₂H₃₆Cl₂Cu₂N₂O₂
          Structure formulaStructure formula
          Purity≥95% by Elemental Analysis
          SolubilityDMSO (0.5 mg/ml). Poorly soluble in water.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot, freeze (≥-70°C). Stock solutions are stable for up to 12 months at ≥-70°C.
          Toxicity Standard Handling
          ReferencesTian, W., et al. 2012. Biochemistry 51, 724.
          Rogers, J.P., et al. 2006. J. Med. Chem. 49, 1658.
          Daniel, K.G., et al. 2004. Biochem. Pharmacol. 67, 1139.