203391 | (-)-Blebbistatin - CAS 856925-71-8 - Calbiochem

203391
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₁₆N₂O₂ 856925-71-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      203391-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewThe active enantiomer of (±)-Blebbistatin (Cat. No. 203390) that accounts for the inhibitory activity towards ATPase (IC50 = ~2 µM) and myosin II-dependent cellular processes. Also reported to potently inhibit the actomyosin ATPase activities of expressed smooth muscle myosin IIA (SMA) and smooth muscle myosin IIB (SMB) smooth muscle myosin II heavy-chain isoforms (IC50 ~3 µM).
          Catalogue Number203391
          Brand Family Calbiochem®
          References
          ReferencesEddinger, T.J. et al. 2007. J. Pharmacol. Exp. Ther. 320, 865.
          Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472.
          Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557.
          Straight, A.F., et al. 2003. Science 299, 1743.
          Product Information
          CAS number856925-71-8
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₈H₁₆N₂O₂
          Chemical formulaC₁₈H₁₆N₂O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetATPase
          Primary Target IC<sub>50</sub>2 µM
          Purity≥98% by Chiral HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Harmful & Carcinogenic / Teratogenic
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month in 90% DMSO or methanol (-20°C). Stock solutions in 100% DMSO are unstable; reconstitute just prior to use.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          203391

          References

          Reference overview
          Eddinger, T.J. et al. 2007. J. Pharmacol. Exp. Ther. 320, 865.
          Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472.
          Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557.
          Straight, A.F., et al. 2003. Science 299, 1743.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-March-2011 RFH
          DescriptionThe active enantiomer of (±)-Blebbistatin (Cat. No. 203390) that accounts for the inhibitory activity toward ATPase (IC50 ~2 µM) and myosin II-dependent cellular processes. Also reported to potently inhibit the actomyosin ATPase activities of expressed smooth muscle myosin IIA (SMA) and smooth muscle myosin IIB (SMB) smooth muscle myosin II heavy-chain isoforms (IC50 ~3 µM).
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number856925-71-8
          Chemical formulaC₁₈H₁₆N₂O₂
          Structure formulaStructure formula
          Purity≥98% by Chiral HPLC
          Solubility100% DMSO (100 mg/ml), 90% DMSO (75 mg/ml) or Methanol (1.5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month in 90% DMSO or methanol (-20°C). Stock solutions in 100% DMSO are unstable; reconstitute just prior to use.
          Toxicity Harmful & Carcinogenic / Teratogenic
          ReferencesEddinger, T.J. et al. 2007. J. Pharmacol. Exp. Ther. 320, 865.
          Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472.
          Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557.
          Straight, A.F., et al. 2003. Science 299, 1743.