200487 β-Amyloid Oligomer Inhibitor, K01-162 - Calbiochem

200487
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₅H₁₄BrN

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      200487-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA cell permeable, fluorene compound that destabilizes the aggregation state of β-amyloid oligomers (AβO) by directly targeting AβO and inhibiting AβO binding to synapses. It displays full MC65 protection at 125 nM, with an EC50 of 80 nM in a neuronal MC65 culture-based assay, and substantially reduces intraneuronal AβO in primary neuronal culture at concentrations between 100 nM and 10 µM. Furthermore, it is shown to significantly reduce amyloid levels by 50% compared with control in vivo in a 5xFAD mice cerebral Aβ amyloidosis model when dosed intracerebroventricularly without apparent toxicity.
          Catalogue Number200487
          Brand Family Calbiochem®
          SynonymsAβO Inhibitor, K01-162
          References
          ReferencesHong, H-S., et al. 2010. Neurobiol. Aging 31, 1690.
          Product Information
          FormWhite to off-white solid
          Hill FormulaC₁₅H₁₄BrN
          Chemical formulaC₁₅H₁₄BrN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          200487

          References

          Reference overview
          Hong, H-S., et al. 2010. Neurobiol. Aging 31, 1690.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision23-March-2018 JSW
          SynonymsAβO Inhibitor, K01-162
          DescriptionA cell permeable, fluorene compound that destabilizes the aggregation state of β-amyloid oligomers (AβO) by directly targeting AβO and inhibiting AβO binding to synapses. It displays full MC65 protection at 125 nM, with an EC50 of 80 nM in a neuronal MC65 culture-based assay, and substantially reduces intraneuronal AβO in primary neuronal culture at concentrations between 100 nM and 10 µM. Furthermore, it is shown to significantly reduce amyloid levels by 50% compared with control in vivo in a 5xFAD mice cerebral Aβ amyloidosis model when dosed intracerebroventricularly without apparent toxicity.
          FormWhite to off-white solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₅H₁₄BrN
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesHong, H-S., et al. 2010. Neurobiol. Aging 31, 1690.