475878 (+)-MK 801 Maleate - CAS 77086-22-7 - Calbiochem

475878
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₅N · C₄H₄O₄ 77086-22-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      475878-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA highly potent, selective, and non-competitive NMDA receptor antagonist that acts by binding to a site located within the NMDA-associated ion channel, thus preventing Ca2+ flux. An effective anti-ischemic agent in several animal models. Has been used to develop an in vivo model of NMDA receptor-dependent apoptotic neurodegenerative disease in developing rat brains. Has also been used to develop an in vitro model of NMDA receptor-specific Ca2+ entry induced seizures.
          Catalogue Number475878
          Brand Family Calbiochem®
          Synonyms(5R,10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5-10-imine, Maleate, Dizocilpine Maleate, NMDA Antagonist I
          References
          ReferencesIkonomidou, C., et al. 1999. Science 283, 70.
          DeLorenzo, R.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14482.
          Woodruff, G.N., et al. 1987. Neuropharmacology 26, 903.
          Wong, E.H.F., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 7104.
          Product Information
          CAS number77086-22-7
          FormWhite solid
          Hill FormulaC₁₆H₁₅N · C₄H₄O₄
          Chemical formulaC₁₆H₁₅N · C₄H₄O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetNMDA receptor
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution in water refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Aqueous stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          475878

          References

          Reference overview
          Ikonomidou, C., et al. 1999. Science 283, 70.
          DeLorenzo, R.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14482.
          Woodruff, G.N., et al. 1987. Neuropharmacology 26, 903.
          Wong, E.H.F., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 7104.

          Brochure

          Title
          Excitotoxic Glutamate Analogs Technical Bulletin
          Pathways and Biomarkers of Glutamatergic Synapse Flyer (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-January-2010 JSW
          Synonyms(5R,10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5-10-imine, Maleate, Dizocilpine Maleate, NMDA Antagonist I
          DescriptionA highly potent, selective and non-competitive NMDA receptor antagonist that acts by binding to a site located within the NMDA associated ion channel, preventing Ca2+ flux. An effective anti-ischemic agent in several animal models. Has been used to develop an in vivo model of NMDA receptor-dependent apoptotic neurodegenerative disease in developing rat brains. Has also been used to develop an in vitro model of NMDA receptor-specific Ca2+ entry induced seizures.
          FormWhite solid
          CAS number77086-22-7
          Chemical formulaC₁₆H₁₅N · C₄H₄O₄
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityEthanol or H₂O (3 mg/ml). Stock solutions in water may require warming and vigorous stirring to achieve complete solubilization.
          Storage +2°C to +8°C
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution in water refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Aqueous stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
          Toxicity Standard Handling
          Merck USA index14, 3386
          ReferencesIkonomidou, C., et al. 1999. Science 283, 70.
          DeLorenzo, R.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14482.
          Woodruff, G.N., et al. 1987. Neuropharmacology 26, 903.
          Wong, E.H.F., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 7104.