203729 | (+)-Brefeldin A, Eupenicillium brefeldianum - CAS 20350-15-6 - Calbiochem

203729
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₂₄O₄ 20350-15-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      203729-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewSpecifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis or lysosome function. Inhibitor of HDL-mediated cholesterol efflux. Causes disassembly of the Golgi complex and ER swelling in a variety of mammalian cell lines at <40 ng/ml. Blocks binding of ADP-ribosylation factor to the Golgi and inhibits the GDP-GTP exchange. Inhibits the activity of BIG1 and BIG2, the guanine-nucleotide exchange proteins for ADP-ribosylation factors. Also available as a 25 mM solution in DMSO (Cat. No. 500583).
          Catalogue Number203729
          Brand Family Calbiochem®
          Synonyms1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one
          References
          ReferencesYamagi, R., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2567.
          Moriango, N., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 12856.
          Mendez, A.J. 1995. J. Biol. Chem. 270, 5891.
          Ridgway, N.D., et al. 1995. J. Biol. Chem. 270, 8023.
          Tsai, S.C., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3063.
          Ktistakis, N.Y., et al. 1992. Nature 356, 344.
          Product Information
          CAS number20350-15-6
          ATP CompetitiveN
          FormWhite crystalline solid
          Hill FormulaC₁₆H₂₄O₄
          Chemical formulaC₁₆H₂₄O₄
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Application(+)-Brefeldin A, Eupenicillium brefeldianum, CAS 20350-15-6, specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum to the Golgi apparatus.
          Biological Information
          Primary TargetBlocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSGY8410000
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 2 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          203729

          References

          Reference overview
          Yamagi, R., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2567.
          Moriango, N., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 12856.
          Mendez, A.J. 1995. J. Biol. Chem. 270, 5891.
          Ridgway, N.D., et al. 1995. J. Biol. Chem. 270, 8023.
          Tsai, S.C., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3063.
          Ktistakis, N.Y., et al. 1992. Nature 356, 344.

          Citations

          Title
        • Michael Tscharntke, et al. (2005) Ras-induced spreading and wound closure in human epidermal keratinocytes. The FASEB Journal in press,.
        • Jenny J.L. Ho, et al. (2003) N-glycosylation is required for the surface localization of MUC17 mucin. 23, 585-592.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision21-August-2009 RFH
          Synonyms1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one
          DescriptionSpecifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis or lysosome function. Inhibitor of HDL-mediated cholesterol efflux. Causes disassembly of the Golgi complex and ER swelling in a variety of mammalian cell lines at <40 ng/ml. Inhibits the activity of BIG1 and BIG2, the guanine-nucleotide exchange proteins for ADP-ribosylation factors. Blocks binding of ADP-ribosylation factor to the Golgi and inhibits the GDP-GTP exchange.
          FormWhite crystalline solid
          CAS number20350-15-6
          RTECSGY8410000
          Chemical formulaC₁₆H₂₄O₄
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityMethanol (2 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 2 months at -20°C.
          Toxicity Harmful
          Merck USA index14, 1369
          ReferencesYamagi, R., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2567.
          Moriango, N., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 12856.
          Mendez, A.J. 1995. J. Biol. Chem. 270, 5891.
          Ridgway, N.D., et al. 1995. J. Biol. Chem. 270, 8023.
          Tsai, S.C., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3063.
          Ktistakis, N.Y., et al. 1992. Nature 356, 344.
          Citation
        • Michael Tscharntke, et al. (2005) Ras-induced spreading and wound closure in human epidermal keratinocytes. The FASEB Journal in press,.
        • Jenny J.L. Ho, et al. (2003) N-glycosylation is required for the surface localization of MUC17 mucin. 23, 585-592.